Prognosis of patients with alpha1-antitrypsine deficiency on long-term oxygen therapy
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Prognosis of patients with alpha1-antitrypsine deficiency on long-term oxygen therapy. / Ringbaek, Thomas J; Seersholm, Niels; Perch, Michael; Iversen, Martin; Lange, Peter.
I: Respiratory Medicine, Bind 108, Nr. 8, 08.2014, s. 1189–1194.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Prognosis of patients with alpha1-antitrypsine deficiency on long-term oxygen therapy
AU - Ringbaek, Thomas J
AU - Seersholm, Niels
AU - Perch, Michael
AU - Iversen, Martin
AU - Lange, Peter
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2014/8
Y1 - 2014/8
N2 - INTRODUCTION: Data on patients with alpha1-antitrypsine deficiency (AATD) on long-term oxygen therapy (LTOT) is sparse. The aim of this study was to present the incidence of patients with AATD on LTOT, and compare their characteristics, comorbidities and prognosis (lung transplantation, termination of LTOT, and survival) with COPD patients without AATD.METHODS: A National prospective study of all COPD patients who started LTOT for the first time in the period 01.11.1994 to 31.12.2010.RESULTS: Among the 21,964 patients on LTOT, 234 patients had AATD. AATD patients were more often males and were on average about 17 years younger than patients without AATD. Cardio-vascular diseases and diabetes mellitus were significantly less prevalent among patients with AATD (60.4% versus 70.3% (P < 0.001) and 4.7% versus 12.2% (P < 0.001)), whereas osteoporosis was more frequent (28.5% versus 20.4%, p = 0.002. Eighty-nine (38.0%) AATD patients and 173 (0.8%) non-AATD patients were lung transplanted in the study period. Median survival was 8.7 years in AATD patients with lung transplantation, 3.3 years in AATD patients without lung transplantation, 6.3 years in non-AATD patients with lung transplantation, and 1.6 years in non-AATD without lung transplantation. Even after adjustment for gender, age, comorbidities, and the time between start of LTOT and lung transplantation, patients with AATD had a lower risk of death compared to non-AATD patients (Hazard ratio 0.73 (95% CI: 0.62-0.86; P < 0.001).CONCLUSIONS: Compared with COPD without AATD, AATD patients are younger, more often males, have a lower prevalence of cardio-vascular diseases and diabetes mellitus, and higher prevalence of osteoporosis. Moreover, they have better prognosis, partly due to greater chance of receiving a lung transplantation.
AB - INTRODUCTION: Data on patients with alpha1-antitrypsine deficiency (AATD) on long-term oxygen therapy (LTOT) is sparse. The aim of this study was to present the incidence of patients with AATD on LTOT, and compare their characteristics, comorbidities and prognosis (lung transplantation, termination of LTOT, and survival) with COPD patients without AATD.METHODS: A National prospective study of all COPD patients who started LTOT for the first time in the period 01.11.1994 to 31.12.2010.RESULTS: Among the 21,964 patients on LTOT, 234 patients had AATD. AATD patients were more often males and were on average about 17 years younger than patients without AATD. Cardio-vascular diseases and diabetes mellitus were significantly less prevalent among patients with AATD (60.4% versus 70.3% (P < 0.001) and 4.7% versus 12.2% (P < 0.001)), whereas osteoporosis was more frequent (28.5% versus 20.4%, p = 0.002. Eighty-nine (38.0%) AATD patients and 173 (0.8%) non-AATD patients were lung transplanted in the study period. Median survival was 8.7 years in AATD patients with lung transplantation, 3.3 years in AATD patients without lung transplantation, 6.3 years in non-AATD patients with lung transplantation, and 1.6 years in non-AATD without lung transplantation. Even after adjustment for gender, age, comorbidities, and the time between start of LTOT and lung transplantation, patients with AATD had a lower risk of death compared to non-AATD patients (Hazard ratio 0.73 (95% CI: 0.62-0.86; P < 0.001).CONCLUSIONS: Compared with COPD without AATD, AATD patients are younger, more often males, have a lower prevalence of cardio-vascular diseases and diabetes mellitus, and higher prevalence of osteoporosis. Moreover, they have better prognosis, partly due to greater chance of receiving a lung transplantation.
KW - Cardiovascular Diseases
KW - Diabetes Complications
KW - Female
KW - Humans
KW - Long-Term Care
KW - Lung Transplantation
KW - Male
KW - Middle Aged
KW - Osteoporosis
KW - Oxygen
KW - Prognosis
KW - Prospective Studies
KW - Pulmonary Disease, Chronic Obstructive
KW - Sex Factors
KW - alpha 1-Antitrypsin Deficiency
U2 - 10.1016/j.rmed.2014.05.001
DO - 10.1016/j.rmed.2014.05.001
M3 - Journal article
C2 - 24906692
VL - 108
SP - 1189
EP - 1194
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 8
ER -
ID: 135785448