PPARgamma-PGC-1alpha activity is determinant of alcohol related breast cancer
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Alcohol is a risk factor for postmenopausal breast cancer. One of several proposed mechanisms is that alcohol-related breast cancer is caused by increased sex hormone levels. PPAR¿ inhibits aromatase transcription in breast adipocytes. We reproduced previously found allele-specific effects of the wildtype Pro-allele of PPARG Pro(12)Ala in alcohol related breast cancer. In transiently transfected cells, transcriptional activation by PPAR¿ and the PPAR¿-PGC-1a complex was inhibited by ethanol. PPAR¿ 12Ala-mediated transcription activation was not enhanced by PGC-1a, resulting in allele-specific transcription activation by the PPAR¿ 12Pro-PGC-1a complex. Our results suggest that PPAR¿ and PGC-1a activity is an important determinant of alcohol related breast cancer.
Originalsprog | Engelsk |
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Tidsskrift | Cancer Letters |
Vol/bind | 315 |
Udgave nummer | 1 |
Sider (fra-til) | 59-68 |
Antal sider | 10 |
ISSN | 0304-3835 |
DOI | |
Status | Udgivet - 2012 |
ID: 35396657