Post-Transplant Diabetes Mellitus and Prediabetes in Renal Transplant Recipients: An Update
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Post-transplant diabetes mellitus (PTDM) is a frequent and relevant complication after renal transplantation: it affects 20-30% of renal transplant recipients and increases the risk for cardiovascular and infectious events. Thus, understanding pathogenesis of PTDM would help limiting its consequences. In this review, we analyse novel aspects of PTDM, based on studies of the last decade, such as the clinical evolution of PTDM, early and late, the reversibility rate, diagnostic criteria, risk factors, including pre-transplant metabolic syndrome and insulin resistance (IR) and the interaction between these factors and immunosuppressive medications. Also, we discuss novel pathogenic factors, in particular the role of β-cell function in an environment of IR and common pathways between pre-existing cell damage and tacrolimus-induced toxicity. The relevant role of prediabetes in the pathogenesis of PTDM and cardiovascular disease is also addressed. Finally, current evidence on PTDM treatment is discussed.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Nephron |
Vol/bind | 145 |
Udgave nummer | 4 |
Sider (fra-til) | 317-329 |
Antal sider | 13 |
ISSN | 1660-8151 |
DOI | |
Status | Udgivet - 2021 |
Bibliografisk note
Funding Information:
Raúl Morales Febles has a grant PFIS FI17/03003 of the Insti-tutodeSaludCarlosIII,NataliaNegrínMenahasaPTA2016/13193/I, MINECO, Armando Torres Ramírez (PI19/01187), Instituto de Tecnologías Biométicas (ITB), University of La Laguna, the IM-BRAIN project for support (FP7-RE6-POT-2012-CT2012-31637-IMBRAIN) funded under the 7th Frameworks Programme capacities. EP is a researcher of the Programme Ramón y Cajal (Grant No. RYC-2014-16573). Red de Investigación Renal (REDinREN) (Grant No. RD16/0009/0031).
Funding Information:
PFIS FI17/03003 of the Instituto de Salud Carlos III
Publisher Copyright:
© 2021 S. Karger AG, Basel. Copyright: All rights reserved.
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