Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears. / Liu, Shiping; Lorenzen, Eline; Fumagalli, Matteo; Li, Bo; Harris, Kelley; Xiong, Zijun; Zhou, Long; Korneliussen, Thorfinn Sand; Somel, Mehmet; Babbitt, Courtney; Wray, Greg; Li, Jianwen; He, Weiming; Wang, Zhuo; Fu, Wenjing; Xiang, Xueyan; Morgan, Claire C.; Doherty, Aoife; O'Connell, Mary J.; McInerney, James O.; Born, Erik W.; Dalén, Love; Dietz, Rune; Orlando, Ludovic Antoine Alexandre; Sonne, Christian; Zhang, Guojie; Nielsen, Rasmus; Willerslev, Eske; Wang, Jun.
I: Cell, Bind 157, Nr. 4, 2014, s. 785-794.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Population genomics reveal recent speciation and rapid evolutionary adaptation in polar bears
AU - Liu, Shiping
AU - Lorenzen, Eline
AU - Fumagalli, Matteo
AU - Li, Bo
AU - Harris, Kelley
AU - Xiong, Zijun
AU - Zhou, Long
AU - Korneliussen, Thorfinn Sand
AU - Somel, Mehmet
AU - Babbitt, Courtney
AU - Wray, Greg
AU - Li, Jianwen
AU - He, Weiming
AU - Wang, Zhuo
AU - Fu, Wenjing
AU - Xiang, Xueyan
AU - Morgan, Claire C.
AU - Doherty, Aoife
AU - O'Connell, Mary J.
AU - McInerney, James O.
AU - Born, Erik W.
AU - Dalén, Love
AU - Dietz, Rune
AU - Orlando, Ludovic Antoine Alexandre
AU - Sonne, Christian
AU - Zhang, Guojie
AU - Nielsen, Rasmus
AU - Willerslev, Eske
AU - Wang, Jun
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2014
Y1 - 2014
N2 - Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans. PAPERCLIP:
AB - Polar bears are uniquely adapted to life in the High Arctic and have undergone drastic physiological changes in response to Arctic climates and a hyperlipid diet of primarily marine mammal prey. We analyzed 89 complete genomes of polar bear and brown bear using population genomic modeling and show that the species diverged only 479-343 thousand years BP. We find that genes on the polar bear lineage have been under stronger positive selection than in brown bears; nine of the top 16 genes under strong positive selection are associated with cardiomyopathy and vascular disease, implying important reorganization of the cardiovascular system. One of the genes showing the strongest evidence of selection, APOB, encodes the primary lipoprotein component of low-density lipoprotein (LDL); functional mutations in APOB may explain how polar bears are able to cope with life-long elevated LDL levels that are associated with high risk of heart disease in humans. PAPERCLIP:
U2 - 10.1016/j.cell.2014.03.054
DO - 10.1016/j.cell.2014.03.054
M3 - Journal article
C2 - 24813606
VL - 157
SP - 785
EP - 794
JO - Cell
JF - Cell
SN - 0092-8674
IS - 4
ER -
ID: 110471738