Plasmodium falciparum infection early in pregnancy has profound consequences for fetal growth
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Plasmodium falciparum infection early in pregnancy has profound consequences for fetal growth. / Schmiegelow, Christentze; Matondo, Sungwa; Minja, Daniel T R; Resende, Mafalda; Pehrson, Caroline; Nielsen, Birgitte Bruun; Olomi, Raimos; Nielsen, Morten A; Deloron, Philippe; Salanti, Ali; Lusingu, John; Theander, Thor G.
I: The Journal of Infectious Diseases, Bind 216, Nr. 12, 19.12.2017, s. 1601-1610.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Plasmodium falciparum infection early in pregnancy has profound consequences for fetal growth
AU - Schmiegelow, Christentze
AU - Matondo, Sungwa
AU - Minja, Daniel T R
AU - Resende, Mafalda
AU - Pehrson, Caroline
AU - Nielsen, Birgitte Bruun
AU - Olomi, Raimos
AU - Nielsen, Morten A
AU - Deloron, Philippe
AU - Salanti, Ali
AU - Lusingu, John
AU - Theander, Thor G
N1 - © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
PY - 2017/12/19
Y1 - 2017/12/19
N2 - Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95% confidence interval {CI}, 26-188]; P = .0099) and a shorter pregnancy duration (difference between means, 6.6 days [95% CI, 1.0-112.5]; P = .0087). The birth weight (difference between means, 221 g [95% CI, 6-436]; P = .044) and the placental weight (difference between means, 84 g [95% CI, 18-150]; P = .013) at term were also reduced. The study suggests that early exposure to P. falciparum, which is not targeted for prevention by current control strategies, has a profound impact on fetal growth, pregnancy duration, and placental weight at term.
AB - Malaria during pregnancy constitutes a large health problem in areas of endemicity. The World Health Organization recommends that interventions are initiated at the first antenatal visit, and these improve pregnancy outcomes. This study evaluated fetal growth by ultrasonography and birth outcomes in women who were infected prior to the first antenatal visit (gestational age, <120 days) and not later in pregnancy. Compared with uninfected controls, women with early Plasmodium falciparum exposure had retarded intrauterine growth between gestational ages of 212 and 253 days (difference between means, 107 g [95% confidence interval {CI}, 26-188]; P = .0099) and a shorter pregnancy duration (difference between means, 6.6 days [95% CI, 1.0-112.5]; P = .0087). The birth weight (difference between means, 221 g [95% CI, 6-436]; P = .044) and the placental weight (difference between means, 84 g [95% CI, 18-150]; P = .013) at term were also reduced. The study suggests that early exposure to P. falciparum, which is not targeted for prevention by current control strategies, has a profound impact on fetal growth, pregnancy duration, and placental weight at term.
KW - Journal Article
U2 - 10.1093/infdis/jix530
DO - 10.1093/infdis/jix530
M3 - Journal article
C2 - 29029247
VL - 216
SP - 1601
EP - 1610
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 12
ER -
ID: 187289802