Plasma Soluble CD163 Level Independently Predicts All-Cause Mortality in HIV-1-Infected Individuals
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Background: CD163, a monocyte- and macrophage-specific scavenger receptor, is shed as soluble CD163 (sCD163) during the proinflammatory response. Here, we assessed the association between plasma sCD163 levels and progression to AIDS and all-cause mortality among individuals infected with human immunodeficiency virus type 1 (HIV).
Methods: Plasma sCD163 levels were measured in 933 HIV–infected individuals. Hazard ratios (HRs) with 95% confidence intervals (CIs) associated with mortality were computed by Cox proportional hazards regression.
Results: At baseline, 86% were receiving antiretroviral treatment, 73% had plasma a HIV RNA level of <50 copies/mL, and the median CD4+ T-cell count was 503 cells/µL. During 10.5 years of follow-up, 167 (17.9%) died. Plasma sCD163 levels were higher in nonsurvivors than in survivors (4.92 mg/L [interquartile range {IQR}, 3.29–8.65 mg/L] vs 3.16 mg/L [IQR, 2.16–4.64 mg/L]; P = .0001). The cumulative incidence of death increased with increasing plasma sCD163 levels, corresponding to a 6% or 35% increased risk of death for each milligram per liter or quartile increase, respectively, in baseline plasma sCD163 level (adjusted HR, 1.06 [95% CI, 1.03–1.09] and 1.35 [95% CI, 1.13–1.63], respectively).
Conclusions: Plasma sCD163 was an independent marker of all-cause mortality in a cohort of HIV–infected individuals, suggesting that monocyte/macrophage activation may play a role in HIV pathogenesis and be a target of intervention.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Infectious Diseases |
Vol/bind | 214 |
Udgave nummer | 8 |
Sider (fra-til) | 1198-1204 |
Antal sider | 7 |
ISSN | 0022-1899 |
DOI | |
Status | Udgivet - 15 okt. 2016 |
ID: 168926587