PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

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Standard

PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. / Kim, Dongha; Nam, Hye Jin; Lee, Wonhwa; Yim, Hwa Young; Ahn, Jun-Yeong; Park, Se Won; Shin, Hi-Jai R; Yu, Reynold; Won, Kyoung-Jae; Bae, Jong-Sup; Kim, Keun Il; Baek, Sung Hee.

I: Molecular Cell, Bind 69, Nr. 3, 01.02.2018, s. 398-411.e6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Kim, D, Nam, HJ, Lee, W, Yim, HY, Ahn, J-Y, Park, SW, Shin, H-JR, Yu, R, Won, K-J, Bae, J-S, Kim, KI & Baek, SH 2018, 'PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response', Molecular Cell, bind 69, nr. 3, s. 398-411.e6. https://doi.org/10.1016/j.molcel.2018.01.002

APA

Kim, D., Nam, H. J., Lee, W., Yim, H. Y., Ahn, J-Y., Park, S. W., Shin, H-J. R., Yu, R., Won, K-J., Bae, J-S., Kim, K. I., & Baek, S. H. (2018). PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. Molecular Cell, 69(3), 398-411.e6. https://doi.org/10.1016/j.molcel.2018.01.002

Vancouver

Kim D, Nam HJ, Lee W, Yim HY, Ahn J-Y, Park SW o.a. PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. Molecular Cell. 2018 feb. 1;69(3):398-411.e6. https://doi.org/10.1016/j.molcel.2018.01.002

Author

Kim, Dongha ; Nam, Hye Jin ; Lee, Wonhwa ; Yim, Hwa Young ; Ahn, Jun-Yeong ; Park, Se Won ; Shin, Hi-Jai R ; Yu, Reynold ; Won, Kyoung-Jae ; Bae, Jong-Sup ; Kim, Keun Il ; Baek, Sung Hee. / PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response. I: Molecular Cell. 2018 ; Bind 69, Nr. 3. s. 398-411.e6.

Bibtex

@article{8d8d8cbd53414368bdcc18946fb256eb,

title = "PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response",

abstract = "The inflammatory response mediated by nuclear factor κB (NF-κB) signaling is essential for host defense against pathogens. Although the regulatory mechanism of NF-κB signaling has been well studied, the molecular basis for epigenetic regulation of the inflammatory response is poorly understood. Here we identify a new signaling axis of PKCα-LSD1-NF-κB, which is critical for activation and amplification of the inflammatory response. In response to excessive inflammatory stimuli, PKCα translocates to the nucleus and phosphorylates LSD1. LSD1 phosphorylation is required for p65 binding and facilitates p65 demethylation, leading to enhanced stability. In vivo genetic analysis using Lsd1SA/SA mice with ablation of LSD1 phosphorylation and chemical approaches in wild-type mice with inhibition of PKCα or LSD1 activity show attenuated sepsis-induced inflammatory lung injury and mortality. Together, we demonstrate that the PKCα-LSD1-NF-κB signaling cascade is crucial for epigenetic control of the inflammatory response, and targeting this signaling could be a powerful therapeutic strategy for systemic inflammatory diseases, including sepsis.",

author = "Dongha Kim and Nam, {Hye Jin} and Wonhwa Lee and Yim, {Hwa Young} and Jun-Yeong Ahn and Park, {Se Won} and Shin, {Hi-Jai R} and Reynold Yu and Kyoung-Jae Won and Jong-Sup Bae and Kim, {Keun Il} and Baek, {Sung Hee}",

year = "2018",

month = feb,

day = "1",

doi = "10.1016/j.molcel.2018.01.002",

language = "English",

volume = "69",

pages = "398--411.e6",

journal = "Molecular Cell",

issn = "1097-2765",

publisher = "Cell Press",

number = "3",

}

RIS

TY - JOUR

T1 - PKCα-LSD1-NF-κB-Signaling Cascade Is Crucial for Epigenetic Control of the Inflammatory Response

AU - Kim, Dongha

AU - Nam, Hye Jin

AU - Lee, Wonhwa

AU - Yim, Hwa Young

AU - Ahn, Jun-Yeong

AU - Park, Se Won

AU - Shin, Hi-Jai R

AU - Yu, Reynold

AU - Won, Kyoung-Jae

AU - Bae, Jong-Sup

AU - Kim, Keun Il

AU - Baek, Sung Hee

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The inflammatory response mediated by nuclear factor κB (NF-κB) signaling is essential for host defense against pathogens. Although the regulatory mechanism of NF-κB signaling has been well studied, the molecular basis for epigenetic regulation of the inflammatory response is poorly understood. Here we identify a new signaling axis of PKCα-LSD1-NF-κB, which is critical for activation and amplification of the inflammatory response. In response to excessive inflammatory stimuli, PKCα translocates to the nucleus and phosphorylates LSD1. LSD1 phosphorylation is required for p65 binding and facilitates p65 demethylation, leading to enhanced stability. In vivo genetic analysis using Lsd1SA/SA mice with ablation of LSD1 phosphorylation and chemical approaches in wild-type mice with inhibition of PKCα or LSD1 activity show attenuated sepsis-induced inflammatory lung injury and mortality. Together, we demonstrate that the PKCα-LSD1-NF-κB signaling cascade is crucial for epigenetic control of the inflammatory response, and targeting this signaling could be a powerful therapeutic strategy for systemic inflammatory diseases, including sepsis.

AB - The inflammatory response mediated by nuclear factor κB (NF-κB) signaling is essential for host defense against pathogens. Although the regulatory mechanism of NF-κB signaling has been well studied, the molecular basis for epigenetic regulation of the inflammatory response is poorly understood. Here we identify a new signaling axis of PKCα-LSD1-NF-κB, which is critical for activation and amplification of the inflammatory response. In response to excessive inflammatory stimuli, PKCα translocates to the nucleus and phosphorylates LSD1. LSD1 phosphorylation is required for p65 binding and facilitates p65 demethylation, leading to enhanced stability. In vivo genetic analysis using Lsd1SA/SA mice with ablation of LSD1 phosphorylation and chemical approaches in wild-type mice with inhibition of PKCα or LSD1 activity show attenuated sepsis-induced inflammatory lung injury and mortality. Together, we demonstrate that the PKCα-LSD1-NF-κB signaling cascade is crucial for epigenetic control of the inflammatory response, and targeting this signaling could be a powerful therapeutic strategy for systemic inflammatory diseases, including sepsis.

U2 - 10.1016/j.molcel.2018.01.002

DO - 10.1016/j.molcel.2018.01.002

M3 - Journal article

C2 - 29395062

VL - 69

SP - 398-411.e6

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 3

ER -

ID: 199325445