Phytocannabinoids: Origins and Biosynthesis

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Phytocannabinoids : Origins and Biosynthesis. / Gülck, Thies; Møller, Birger Lindberg.

I: Trends in Plant Science, Bind 25, Nr. 10, 2020, s. 985-1004.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Gülck, T & Møller, BL 2020, 'Phytocannabinoids: Origins and Biosynthesis', Trends in Plant Science, bind 25, nr. 10, s. 985-1004. https://doi.org/10.1016/j.tplants.2020.05.005

APA

Gülck, T., & Møller, B. L. (2020). Phytocannabinoids: Origins and Biosynthesis. Trends in Plant Science, 25(10), 985-1004. https://doi.org/10.1016/j.tplants.2020.05.005

Vancouver

Gülck T, Møller BL. Phytocannabinoids: Origins and Biosynthesis. Trends in Plant Science. 2020;25(10):985-1004. https://doi.org/10.1016/j.tplants.2020.05.005

Author

Gülck, Thies ; Møller, Birger Lindberg. / Phytocannabinoids : Origins and Biosynthesis. I: Trends in Plant Science. 2020 ; Bind 25, Nr. 10. s. 985-1004.

Bibtex

@article{1f2a4a7dca7b417aa54a500dc226bb3b,
title = "Phytocannabinoids: Origins and Biosynthesis",
abstract = "Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts, and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety, and cachexia. Targeted biosynthesis of cannabinoids with desirable properties requires identification of the underlying genes and their expression in a suitable heterologous host. We provide an overview of the structural classification of phytocannabinoids based on their decorated resorcinol core and the bioactivities of naturally occurring cannabinoids, and we review current knowledge of phytocannabinoid biosynthesis in Cannabis, Rhododendron, and Radula species. We also highlight the potential in planta roles of phytocannabinoids and the opportunity for synthetic biology approaches based on combinatorial biochemistry and protein engineering to produce cannabinoid derivatives with improved properties.",
author = "Thies G{\"u}lck and M{\o}ller, {Birger Lindberg}",
year = "2020",
doi = "10.1016/j.tplants.2020.05.005",
language = "English",
volume = "25",
pages = "985--1004",
journal = "Trends in Plant Science",
issn = "1360-1385",
publisher = "Elsevier Ltd. * Trends Journals",
number = "10",

}

RIS

TY - JOUR

T1 - Phytocannabinoids

T2 - Origins and Biosynthesis

AU - Gülck, Thies

AU - Møller, Birger Lindberg

PY - 2020

Y1 - 2020

N2 - Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts, and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety, and cachexia. Targeted biosynthesis of cannabinoids with desirable properties requires identification of the underlying genes and their expression in a suitable heterologous host. We provide an overview of the structural classification of phytocannabinoids based on their decorated resorcinol core and the bioactivities of naturally occurring cannabinoids, and we review current knowledge of phytocannabinoid biosynthesis in Cannabis, Rhododendron, and Radula species. We also highlight the potential in planta roles of phytocannabinoids and the opportunity for synthetic biology approaches based on combinatorial biochemistry and protein engineering to produce cannabinoid derivatives with improved properties.

AB - Phytocannabinoids are bioactive natural products found in some flowering plants, liverworts, and fungi that can be beneficial for the treatment of human ailments such as pain, anxiety, and cachexia. Targeted biosynthesis of cannabinoids with desirable properties requires identification of the underlying genes and their expression in a suitable heterologous host. We provide an overview of the structural classification of phytocannabinoids based on their decorated resorcinol core and the bioactivities of naturally occurring cannabinoids, and we review current knowledge of phytocannabinoid biosynthesis in Cannabis, Rhododendron, and Radula species. We also highlight the potential in planta roles of phytocannabinoids and the opportunity for synthetic biology approaches based on combinatorial biochemistry and protein engineering to produce cannabinoid derivatives with improved properties.

U2 - 10.1016/j.tplants.2020.05.005

DO - 10.1016/j.tplants.2020.05.005

M3 - Review

C2 - 32646718

AN - SCOPUS:85087512667

VL - 25

SP - 985

EP - 1004

JO - Trends in Plant Science

JF - Trends in Plant Science

SN - 1360-1385

IS - 10

ER -

ID: 248150702