Physical activity and sedentary time across pregnancy and associations with neonatal weight, adiposity and cord blood parameters: a secondary analysis of the DALI study
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Background/Objectives: Obesity during pregnancy is associated with neonatal adiposity, which is a risk factor for childhood obesity. Maternal physical activity (PA) and sedentary behaviours during pregnancy might modify this risk. We therefore studied associations between maternal PA and sedentary time (ST) during pregnancy and neonatal anthropometry and cord blood parameters and investigated whether associations differed by offspring sex. Subjects/Methods: Participants of the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention (DALI) study with a BMI ≥ 29 kg/m2 were analysed as a cohort. Maternal moderate-to-vigorous PA (MVPA) and ST were measured repeatedly with accelerometers across pregnancy. Associations between mean levels and changes in MVPA and ST and birthweight, neonatal adiposity (fat mass (FM)%) and cord blood parameters, including C-peptide, leptin and lipids, were analysed in 213 mother-child pairs with Bayesian multilevel models. Interactions with offspring sex were considered. Results: Almost all women decreased MVPA levels and increased ST throughout gestation. Both higher maternal mean MVPA and increasing MVPA were associated with lower offspring FM% in males (−0.520%; 95% CI: −1.011%, −0.031% and −4.649%; −7.876%, −1.432% respectively). In female offspring, mean ST was associated with lower cord blood C-peptide (−0.145 µg/l; −0.279 µg/l, −0.005 µg/l). No associations were found with birthweight or other cord blood parameters. Conclusions: Maternal MVPA is associated with neonatal fat mass, but not birthweight, in male offspring. Our findings underline the importance of physical activity throughout pregnancy.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | International Journal of Obesity |
| Vol/bind | 47 |
| Udgave nummer | 9 |
| Sider (fra-til) | 873-881 |
| ISSN | 0307-0565 |
| DOI | |
| Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
We would like to thank Erwin Stolz, Medical University of Graz, for his support during data analysis. The DALI project has received funding from the European Community’s 7th Framework Program (FP7/2007–2013) under grant agreement no. 242187. In the Netherlands, additional funding was provided by the Netherlands Organisation for Health Research and Development (ZonMw) (Grant nr. 200310013). In Poland, additional funding was obtained from Polish Ministry of Science (Grant nr 2203/7. PR/2011/2). In Denmark, additional funding was provided by Odense University Free Research Fund. In the UK, the DALI team acknowledges the support received from the NIHR Clinical Research Network: Eastern, especially the local diabetes clinical and research teams based in Cambridge. In Spain, additional funding was provided by CAIBER 1527-B-226. AMD was supported by the Austrian Science Fund FWF (DOC 31-B26) and the Medical University Graz through the PhD Programme Inflammatory Disorders in Pregnancy (DP-iDP). Open access funding provided by the Austrian Science Fund FWF.
Funding Information:
We would like to thank Erwin Stolz, Medical University of Graz, for his support during data analysis. The DALI project has received funding from the European Community’s 7th Framework Program (FP7/2007–2013) under grant agreement no. 242187. In the Netherlands, additional funding was provided by the Netherlands Organisation for Health Research and Development (ZonMw) (Grant nr. 200310013). In Poland, additional funding was obtained from Polish Ministry of Science (Grant nr 2203/7. PR/2011/2). In Denmark, additional funding was provided by Odense University Free Research Fund. In the UK, the DALI team acknowledges the support received from the NIHR Clinical Research Network: Eastern, especially the local diabetes clinical and research teams based in Cambridge. In Spain, additional funding was provided by CAIBER 1527-B-226. AMD was supported by the Austrian Science Fund FWF (DOC 31-B26) and the Medical University Graz through the PhD Programme Inflammatory Disorders in Pregnancy (DP-iDP). Open access funding provided by the Austrian Science Fund FWF.
Publisher Copyright:
© 2023, The Author(s).
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