Perspectives in Immunotherapy: meeting report from the Immunotherapy Bridge, December 1st–2nd, 2021
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Over the past decade, immunotherapy has become an increasingly fundamental modality in the treatment of cancer. The positive impact of immune checkpoint inhibition, especially anti-programmed death (PD)-1/PD-ligand (L)1 blockade, in patients with different cancers has focused attention on the potential for other immunotherapeutic approaches. These include inhibitors of additional immune checkpoints, adoptive cell transfer (ACT), and therapeutic vaccines. Patients with advanced cancers who previously had limited treatment options available may now benefit from immunotherapies that can offer durable responses and improved survival outcomes. However, despite this, a significant proportion of patients fail to respond to immunotherapy, especially those with less immunoresponsive cancer types, and there remains a need for new treatment strategies. The virtual Immunotherapy Bridge (December 1st–2nd, 2021), organized by the Fondazione Melanoma Onlus, Naples, Italy in collaboration with the Society for Immunotherapy of Cancer addressed several areas of current research in immunotherapy, including lessons learned from cell therapies, drivers of immune response, and trends in immunotherapy across different cancers, and these are summarised here.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 257 |
| Tidsskrift | Journal of Translational Medicine |
| Vol/bind | 20 |
| Udgave nummer | 1 |
| ISSN | 1479-5876 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:
Leisha A. Emens (LAE): Honoraria from F Hoffman La Roche, Genentech, Macrogenics, Lilly, Chugai, Silverback, Shionogi, CytomX, GPCR, Immunitas, DNAMx, Gilead, and Mersana; Future stock options from Molecuvax; Research funding from Genentech, F Hoffman La Roche, EMD Serono, Merck, AstraZeneca, Tempest, Bolt, Silverback, Takeda, CytomX, Compugen, Abbvie, BMS, Next Cure, and Immune Onc. She served as a chair the steering committee for IMpassion130, KATE 2, and KATE3.
Funding Information:
Antonio Avallone (AV): reports receiving grant or research support from Amgen, Bayer, and Bristol Myers Squibb, consultant fees from Amgen, Eisai, and MSD, and honoraria from Amgen, AstraZeneca, MSD, and Servier.
Funding Information:
Robert L. Ferris (RLF): reports grants from Astra-Zeneca/MedImmune, Bristol Myers Squibb, Merck, Novasenta, and Tesaro; stock from Novasenta; personal fees from Adagene Inc, Aduro Biotech Inc, Bicara Therapeutics Inc, Bristol Myers Squibb, Brooklyn Immunotherapeutics LLC, Catenion, Coherus BioSciences Inc, Everest Clinical Research Corporation, F. Hoffmann-La Roche Ltd, Genocea Biosciences Inc, Hookipa Biotech GmbH, Instil Bio Inc, Kowa Research Institute Inc, Lifescience Dynamics Limited, MacroGenics Inc, Merck, Mirati Therapeutics Inc, Mirror Biologics Inc, Nanobiotix, Novasenta, Numab Therapeutics AG, OncoCyte Corportation, Pfizer, PPD Development LP, Rakuten Medical Inc, Sanofi, Seagen Inc, Vir Biotechnology Inc, Zymeworks Inc, outside of the submitted work.
Funding Information:
Sandro Pignata (SP): Honoraria from MSD AZ Pfizer Roche GSK Clovis; Research funding from MSD Roche Pfizer AZ.
Publisher Copyright:
© 2022, The Author(s).
ID: 321834156