Paracetamol-induced nephrotoxicity in the absence of hepatotoxicity is only described in a few studies. The aim of this retrospective cohort study with data from the Capital Region of Denmark 2010-2017, was to examine the incidence of possible paracetamol-induced nephrotoxicity in absence of hepatotoxicity. Only one out of 5,827 admissions (0.02%) included in the study developed clinically relevant acute kidney injury (AKI) that could be attributed to paracetamol in absence of acute liver injury. This study demonstrates that clinically relevant AKI due to paracetamol overdose rarely occurs without concomitant hepatic injury when excluding other prerenal, renal, and postrenal causes of renal dysfunction, NAC interference and chronic kidney injury.