P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

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Standard

P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. / Ciofu, Oana; Johansen, Helle Krogh; Aanaes, Kasper; Wassermann, Tina; Alhede, Morten; von Buchwald, Christian; Høiby, Niels.

I: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, Bind 12, Nr. 6, 08.03.2013, s. 729-736.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ciofu, O, Johansen, HK, Aanaes, K, Wassermann, T, Alhede, M, von Buchwald, C & Høiby, N 2013, 'P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs', Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, bind 12, nr. 6, s. 729-736. https://doi.org/10.1016/j.jcf.2013.02.004

APA

Ciofu, O., Johansen, H. K., Aanaes, K., Wassermann, T., Alhede, M., von Buchwald, C., & Høiby, N. (2013). P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 12(6), 729-736. https://doi.org/10.1016/j.jcf.2013.02.004

Vancouver

Ciofu O, Johansen HK, Aanaes K, Wassermann T, Alhede M, von Buchwald C o.a. P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2013 mar. 8;12(6):729-736. https://doi.org/10.1016/j.jcf.2013.02.004

Author

Ciofu, Oana ; Johansen, Helle Krogh ; Aanaes, Kasper ; Wassermann, Tina ; Alhede, Morten ; von Buchwald, Christian ; Høiby, Niels. / P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs. I: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 2013 ; Bind 12, Nr. 6. s. 729-736.

Bibtex

@article{3b361bf69098420cbc7c9ac7c74c6a17,
title = "P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs",
abstract = "BACKGROUND: Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations. METHODS: We studied the genetic basis of phenotypic diversification and gene expression profiles in sequential lung and sinus P. aeruginosa isolates from four chronically infected CF patients, including pre- and post-lung transplantation isolates. RESULTS: The same phenotypes caused by similar mutations and similar gene expression profiles were found in mucoid and non-mucoid isolates from the paranasal sinuses and from the lungs before and after transplantation. CONCLUSION: Bilateral exchange of P. aeruginosa isolates between the paranasal sinuses and the lungs occurs in chronically infected patients and extensive sinus surgery before the lung transplantation might prevent infection of the new lung.",
author = "Oana Ciofu and Johansen, {Helle Krogh} and Kasper Aanaes and Tina Wassermann and Morten Alhede and {von Buchwald}, Christian and Niels H{\o}iby",
note = "Copyright {\textcopyright} 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.",
year = "2013",
month = mar,
day = "8",
doi = "10.1016/j.jcf.2013.02.004",
language = "English",
volume = "12",
pages = "729--736",
journal = "Journal of Cystic Fibrosis",
issn = "1569-1993",
publisher = "Elsevier",
number = "6",

}

RIS

TY - JOUR

T1 - P. aeruginosa in the paranasal sinuses and transplanted lungs have similar adaptive mutations as isolates from chronically infected CF lungs

AU - Ciofu, Oana

AU - Johansen, Helle Krogh

AU - Aanaes, Kasper

AU - Wassermann, Tina

AU - Alhede, Morten

AU - von Buchwald, Christian

AU - Høiby, Niels

N1 - Copyright © 2013 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.

PY - 2013/3/8

Y1 - 2013/3/8

N2 - BACKGROUND: Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations. METHODS: We studied the genetic basis of phenotypic diversification and gene expression profiles in sequential lung and sinus P. aeruginosa isolates from four chronically infected CF patients, including pre- and post-lung transplantation isolates. RESULTS: The same phenotypes caused by similar mutations and similar gene expression profiles were found in mucoid and non-mucoid isolates from the paranasal sinuses and from the lungs before and after transplantation. CONCLUSION: Bilateral exchange of P. aeruginosa isolates between the paranasal sinuses and the lungs occurs in chronically infected patients and extensive sinus surgery before the lung transplantation might prevent infection of the new lung.

AB - BACKGROUND: Pseudomonas aeruginosa cells are present as biofilms in the paranasal sinuses and the lungs of chronically infected cystic fibrosis (CF) patients. Since different inflammatory responses and selective antibiotic pressures are acting in the sinuses compared with the lungs, we compared the adaptive profiles of mucoid and non-mucoid isolates from the two locations. METHODS: We studied the genetic basis of phenotypic diversification and gene expression profiles in sequential lung and sinus P. aeruginosa isolates from four chronically infected CF patients, including pre- and post-lung transplantation isolates. RESULTS: The same phenotypes caused by similar mutations and similar gene expression profiles were found in mucoid and non-mucoid isolates from the paranasal sinuses and from the lungs before and after transplantation. CONCLUSION: Bilateral exchange of P. aeruginosa isolates between the paranasal sinuses and the lungs occurs in chronically infected patients and extensive sinus surgery before the lung transplantation might prevent infection of the new lung.

U2 - 10.1016/j.jcf.2013.02.004

DO - 10.1016/j.jcf.2013.02.004

M3 - Journal article

C2 - 23478131

VL - 12

SP - 729

EP - 736

JO - Journal of Cystic Fibrosis

JF - Journal of Cystic Fibrosis

SN - 1569-1993

IS - 6

ER -

ID: 47490029