Outcome of breast cancer screening in Denmark

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Outcome of breast cancer screening in Denmark. / Lynge, Elsebeth; Bak, Martin; von Euler-Chelpin, My; Kroman, Niels; Lernevall, Anders; Mogensen, Nikolaj Borg; Schwartz, Walter; Wronecki, Adam Jan; Vejborg, Ilse.

I: BMC Cancer, Bind 17, 897, 28.12.2017, s. 1-9.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Lynge, E, Bak, M, von Euler-Chelpin, M, Kroman, N, Lernevall, A, Mogensen, NB, Schwartz, W, Wronecki, AJ & Vejborg, I 2017, 'Outcome of breast cancer screening in Denmark', BMC Cancer, bind 17, 897, s. 1-9. https://doi.org/10.1186/s12885-017-3929-6

APA

Lynge, E., Bak, M., von Euler-Chelpin, M., Kroman, N., Lernevall, A., Mogensen, N. B., ... Vejborg, I. (2017). Outcome of breast cancer screening in Denmark. BMC Cancer, 17, 1-9. [897]. https://doi.org/10.1186/s12885-017-3929-6

Vancouver

Lynge E, Bak M, von Euler-Chelpin M, Kroman N, Lernevall A, Mogensen NB o.a. Outcome of breast cancer screening in Denmark. BMC Cancer. 2017 dec 28;17:1-9. 897. https://doi.org/10.1186/s12885-017-3929-6

Author

Lynge, Elsebeth ; Bak, Martin ; von Euler-Chelpin, My ; Kroman, Niels ; Lernevall, Anders ; Mogensen, Nikolaj Borg ; Schwartz, Walter ; Wronecki, Adam Jan ; Vejborg, Ilse. / Outcome of breast cancer screening in Denmark. I: BMC Cancer. 2017 ; Bind 17. s. 1-9.

Bibtex

@article{92b46d4843234f9d8fc9a1334d22b109,
title = "Outcome of breast cancer screening in Denmark",
abstract = "Background: In Denmark, national roll-out of a population-based, screening mammography program took place in 2007-2010. We report on outcome of the first four biennial invitation rounds. Methods: Data on screening outcome were retrieved from the 2015 and 2016 national screening quality reports. We calculated coverage by examination; participation after invitation; detection-, interval cancer- and false-positive rates; cancer characteristics; sensitivity and specificity, for Denmark and for the five regions. Results: At the national level coverage by examination remained at 75-77{\%}; lower in the Capital Region than in the rest of Denmrk. Detection rate was slightly below 1{\%} at first screen, 0.6{\%} at subsequent screens, and one region had some fluctuation over time. Ductal carcinoma in situ (DCIS) constituted 13-14{\%} of screen-detected cancers. In subsequent rounds, 80{\%} of screen-detected invasive cancers were node negative and 40{\%} ≤10 mm. False-positive rate was around 2{\%}; higher for North Denmark Region than for the rest of Denmark. Three out of 10 breast cancers in screened women were diagnosed as interval cancers. Conclusions: High coverage by examination and low interval cancer rate are required for screening to decrease breast cancer mortality. Two pioneer local screening programs starting in the 1990s were followed by a decrease in breast cancer mortality of 22-25{\%}. Coverage by examination and interval cancer rate of the national program were on the favorable side of values from the pioneer programs. It appears that the implementation of a national screening program in Denmark has been successful, though regional variations need further evaluation to assure optimization of the program.",
keywords = "Breast cancer, Ductal carcinoma in situ, Mammography, Screening",
author = "Elsebeth Lynge and Martin Bak and {von Euler-Chelpin}, My and Niels Kroman and Anders Lernevall and Mogensen, {Nikolaj Borg} and Walter Schwartz and Wronecki, {Adam Jan} and Ilse Vejborg",
year = "2017",
month = "12",
day = "28",
doi = "10.1186/s12885-017-3929-6",
language = "English",
volume = "17",
pages = "1--9",
journal = "B M C Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",

}

RIS

TY - JOUR

T1 - Outcome of breast cancer screening in Denmark

AU - Lynge, Elsebeth

AU - Bak, Martin

AU - von Euler-Chelpin, My

AU - Kroman, Niels

AU - Lernevall, Anders

AU - Mogensen, Nikolaj Borg

AU - Schwartz, Walter

AU - Wronecki, Adam Jan

AU - Vejborg, Ilse

PY - 2017/12/28

Y1 - 2017/12/28

N2 - Background: In Denmark, national roll-out of a population-based, screening mammography program took place in 2007-2010. We report on outcome of the first four biennial invitation rounds. Methods: Data on screening outcome were retrieved from the 2015 and 2016 national screening quality reports. We calculated coverage by examination; participation after invitation; detection-, interval cancer- and false-positive rates; cancer characteristics; sensitivity and specificity, for Denmark and for the five regions. Results: At the national level coverage by examination remained at 75-77%; lower in the Capital Region than in the rest of Denmrk. Detection rate was slightly below 1% at first screen, 0.6% at subsequent screens, and one region had some fluctuation over time. Ductal carcinoma in situ (DCIS) constituted 13-14% of screen-detected cancers. In subsequent rounds, 80% of screen-detected invasive cancers were node negative and 40% ≤10 mm. False-positive rate was around 2%; higher for North Denmark Region than for the rest of Denmark. Three out of 10 breast cancers in screened women were diagnosed as interval cancers. Conclusions: High coverage by examination and low interval cancer rate are required for screening to decrease breast cancer mortality. Two pioneer local screening programs starting in the 1990s were followed by a decrease in breast cancer mortality of 22-25%. Coverage by examination and interval cancer rate of the national program were on the favorable side of values from the pioneer programs. It appears that the implementation of a national screening program in Denmark has been successful, though regional variations need further evaluation to assure optimization of the program.

AB - Background: In Denmark, national roll-out of a population-based, screening mammography program took place in 2007-2010. We report on outcome of the first four biennial invitation rounds. Methods: Data on screening outcome were retrieved from the 2015 and 2016 national screening quality reports. We calculated coverage by examination; participation after invitation; detection-, interval cancer- and false-positive rates; cancer characteristics; sensitivity and specificity, for Denmark and for the five regions. Results: At the national level coverage by examination remained at 75-77%; lower in the Capital Region than in the rest of Denmrk. Detection rate was slightly below 1% at first screen, 0.6% at subsequent screens, and one region had some fluctuation over time. Ductal carcinoma in situ (DCIS) constituted 13-14% of screen-detected cancers. In subsequent rounds, 80% of screen-detected invasive cancers were node negative and 40% ≤10 mm. False-positive rate was around 2%; higher for North Denmark Region than for the rest of Denmark. Three out of 10 breast cancers in screened women were diagnosed as interval cancers. Conclusions: High coverage by examination and low interval cancer rate are required for screening to decrease breast cancer mortality. Two pioneer local screening programs starting in the 1990s were followed by a decrease in breast cancer mortality of 22-25%. Coverage by examination and interval cancer rate of the national program were on the favorable side of values from the pioneer programs. It appears that the implementation of a national screening program in Denmark has been successful, though regional variations need further evaluation to assure optimization of the program.

KW - Breast cancer

KW - Ductal carcinoma in situ

KW - Mammography

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=85039909233&partnerID=8YFLogxK

U2 - 10.1186/s12885-017-3929-6

DO - 10.1186/s12885-017-3929-6

M3 - Journal article

C2 - 29282034

AN - SCOPUS:85039909233

VL - 17

SP - 1

EP - 9

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

M1 - 897

ER -

ID: 188743711