Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates

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Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates. / Li, Yian; Zhang, Guojie; Cui, Jie.

I: Viruses, Bind 14, Nr. 7, 1370, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Li, Y, Zhang, G & Cui, J 2022, 'Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates', Viruses, bind 14, nr. 7, 1370. https://doi.org/10.3390/v14071370

APA

Li, Y., Zhang, G., & Cui, J. (2022). Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates. Viruses, 14(7), [1370]. https://doi.org/10.3390/v14071370

Vancouver

Li Y, Zhang G, Cui J. Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates. Viruses. 2022;14(7). 1370. https://doi.org/10.3390/v14071370

Author

Li, Yian ; Zhang, Guojie ; Cui, Jie. / Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates. I: Viruses. 2022 ; Bind 14, Nr. 7.

Bibtex

@article{887481c7f6414ad58080f86152e829a7,
title = "Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates",
abstract = "Human endogenous retroviruses (HERVs) are viral “fossils” in the human genome that originated from the ancient integration of exogenous retroviruses. Although HERVs have sporadically been reported in nonhuman primate genomes, their deep origination in pan-primates remains to be explored. Hence, based on the in silico genomic mining of full-length HERVs in 49 primates, we performed the largest systematic survey to date of the distribution, phylogeny, and functional predictions of HERVs. Most importantly, we obtained conclusive evidence of nonhuman origin for most contemporary HERVs. We found that various supergroups, including HERVW9, HUERSP, HSERVIII, HERVIPADP, HERVK, and HERVHF, were widely distributed in Strepsirrhini, Platyrrhini (New World monkeys) and Catarrhini (Old World monkeys and apes). We found that numerous HERVHFs are spread by vertical transmission within Catarrhini and one HERVHF was traced in 17 species, indicating its ancient nature. We also discovered that 164 HERVs were likely involved in genomic rearrangement and 107 HERVs were potentially coopted in the form of noncoding RNAs (ncRNAs) in humans. In summary, we provided comprehensive data on the deep origination of modern HERVs in pan-primates.",
keywords = "evolution, genomic rearrangement, human endogenous retroviruses, origin, pan-primates, vertical transmission",
author = "Yian Li and Guojie Zhang and Jie Cui",
note = "Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2022",
doi = "10.3390/v14071370",
language = "English",
volume = "14",
journal = "Viruses",
issn = "1999-4915",
publisher = "M D P I AG",
number = "7",

}

RIS

TY - JOUR

T1 - Origin and Deep Evolution of Human Endogenous Retroviruses in Pan-Primates

AU - Li, Yian

AU - Zhang, Guojie

AU - Cui, Jie

N1 - Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2022

Y1 - 2022

N2 - Human endogenous retroviruses (HERVs) are viral “fossils” in the human genome that originated from the ancient integration of exogenous retroviruses. Although HERVs have sporadically been reported in nonhuman primate genomes, their deep origination in pan-primates remains to be explored. Hence, based on the in silico genomic mining of full-length HERVs in 49 primates, we performed the largest systematic survey to date of the distribution, phylogeny, and functional predictions of HERVs. Most importantly, we obtained conclusive evidence of nonhuman origin for most contemporary HERVs. We found that various supergroups, including HERVW9, HUERSP, HSERVIII, HERVIPADP, HERVK, and HERVHF, were widely distributed in Strepsirrhini, Platyrrhini (New World monkeys) and Catarrhini (Old World monkeys and apes). We found that numerous HERVHFs are spread by vertical transmission within Catarrhini and one HERVHF was traced in 17 species, indicating its ancient nature. We also discovered that 164 HERVs were likely involved in genomic rearrangement and 107 HERVs were potentially coopted in the form of noncoding RNAs (ncRNAs) in humans. In summary, we provided comprehensive data on the deep origination of modern HERVs in pan-primates.

AB - Human endogenous retroviruses (HERVs) are viral “fossils” in the human genome that originated from the ancient integration of exogenous retroviruses. Although HERVs have sporadically been reported in nonhuman primate genomes, their deep origination in pan-primates remains to be explored. Hence, based on the in silico genomic mining of full-length HERVs in 49 primates, we performed the largest systematic survey to date of the distribution, phylogeny, and functional predictions of HERVs. Most importantly, we obtained conclusive evidence of nonhuman origin for most contemporary HERVs. We found that various supergroups, including HERVW9, HUERSP, HSERVIII, HERVIPADP, HERVK, and HERVHF, were widely distributed in Strepsirrhini, Platyrrhini (New World monkeys) and Catarrhini (Old World monkeys and apes). We found that numerous HERVHFs are spread by vertical transmission within Catarrhini and one HERVHF was traced in 17 species, indicating its ancient nature. We also discovered that 164 HERVs were likely involved in genomic rearrangement and 107 HERVs were potentially coopted in the form of noncoding RNAs (ncRNAs) in humans. In summary, we provided comprehensive data on the deep origination of modern HERVs in pan-primates.

KW - evolution

KW - genomic rearrangement

KW - human endogenous retroviruses

KW - origin

KW - pan-primates

KW - vertical transmission

U2 - 10.3390/v14071370

DO - 10.3390/v14071370

M3 - Journal article

C2 - 35891351

AN - SCOPUS:85132985595

VL - 14

JO - Viruses

JF - Viruses

SN - 1999-4915

IS - 7

M1 - 1370

ER -

ID: 316069387