Oil-loaded monolinolein-based particles with confined inverse discontinuous cubic structure (Fd3m)
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Oil-loaded monolinolein-based particles with confined inverse discontinuous cubic structure (Fd3m). / Yaghmur, Anan; De Campo, Liliana; Salentinig, Stefan; Sagalowicz, Laurent; Leser, Martin E.; Glatter, Otto.
I: Langmuir, Bind 22, Nr. 2, 17.01.2006, s. 517-521.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Oil-loaded monolinolein-based particles with confined inverse discontinuous cubic structure (Fd3m)
AU - Yaghmur, Anan
AU - De Campo, Liliana
AU - Salentinig, Stefan
AU - Sagalowicz, Laurent
AU - Leser, Martin E.
AU - Glatter, Otto
PY - 2006/1/17
Y1 - 2006/1/17
N2 - In our recent work, we reported on the effect of varying temperature and solubilizing tetradecane (TC) on the structural transitions observed in dispersed particles based on the monolinolein (MLO)-water-TC system. At a given temperature, the addition of TC induces a transition of the internal structure from the bicontinuous cubic phase, Pn3m, to the reversed hexagonal, H 2, and to the isotropic liquid phase (water-in-oil (W/O) microemulsions). Our present study focuses on the discovery of a Fd3m phase (reversed discontinuous micellar cubic), which is formed in the MLO-water-TC system at a specific TC/MLO weight ratio. It is situated between the H 2 and the isotropic liquid phase (W/O microemulsion). Remarkably, it is not found in the absence of TC by increasing the temperature. The Fd3m structure was investigated in detail by means of small-angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryo-TEM). The present work proves that the structural transformation in the dispersed particles from H2 (hexosomes) to the W/O microemulsion system (emulsified microemulsion (EME)) is indirect and it occurs gradually via an emulsified intermediate phase. Specifically, in addition to the nanostructured aqueous dispersions described above, we present new TC-loaded aqueous dispersions with a confined intermediate phase, which is a discontinuous micellar cubic phase of the symmetry Fd3m. We denoted this type of emulsified particles as "micellar cubosomes".
AB - In our recent work, we reported on the effect of varying temperature and solubilizing tetradecane (TC) on the structural transitions observed in dispersed particles based on the monolinolein (MLO)-water-TC system. At a given temperature, the addition of TC induces a transition of the internal structure from the bicontinuous cubic phase, Pn3m, to the reversed hexagonal, H 2, and to the isotropic liquid phase (water-in-oil (W/O) microemulsions). Our present study focuses on the discovery of a Fd3m phase (reversed discontinuous micellar cubic), which is formed in the MLO-water-TC system at a specific TC/MLO weight ratio. It is situated between the H 2 and the isotropic liquid phase (W/O microemulsion). Remarkably, it is not found in the absence of TC by increasing the temperature. The Fd3m structure was investigated in detail by means of small-angle X-ray scattering (SAXS), and cryogenic transmission electron microscopy (cryo-TEM). The present work proves that the structural transformation in the dispersed particles from H2 (hexosomes) to the W/O microemulsion system (emulsified microemulsion (EME)) is indirect and it occurs gradually via an emulsified intermediate phase. Specifically, in addition to the nanostructured aqueous dispersions described above, we present new TC-loaded aqueous dispersions with a confined intermediate phase, which is a discontinuous micellar cubic phase of the symmetry Fd3m. We denoted this type of emulsified particles as "micellar cubosomes".
UR - http://www.scopus.com/inward/record.url?scp=31544473729&partnerID=8YFLogxK
U2 - 10.1021/la052109w
DO - 10.1021/la052109w
M3 - Journal article
AN - SCOPUS:31544473729
VL - 22
SP - 517
EP - 521
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 2
ER -
ID: 221830571