Oestrogen-free oral contraception with a 4 mg drospirenone-only pill: new data and a review of the literature
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Dokumenter
- Oestrogen free oral contraception with a 4 mg drospirenone only pill new data and a review of the literature
Forlagets udgivne version, 1,24 MB, PDF-dokument
Purpose: The contraceptive pill is an effective and safe method of preventing pregnancy. The progestins used for contraception either are components of a combined hormonal contraceptive (tablets, patches or vaginal rings) or are used alone in progestin-only formulations. Progestin-only contraceptives are available as daily oral preparations, subcutaneous or intramuscular injectables (every 1–3 months), subdermal implants (every 3–5 years) and intrauterine systems (every 3–5 years). Long-acting progestins are highly effective in typical use and have a very low risk profile and few contraindications. Material and Methods: A new progestin-only, oestrogen-free contraceptive, drospirenone, in a dosage of 4 mg/day in a 24/4 regimen, has received regulatory approval in the USA and the EU. The molecule has antigonadotropic, antimineralocorticoid, antiestrogenic and antiandrogenic properties. Results: The regimen was chosen to improve the bleeding profile; maintain plasma oestradiol levels at those of the early follicular phase, to avoid hypoestrogenism; and preserve efficacy even with a missed pill, as drospirenone has a half-life of 30–34 h. Conclusions: Clinical studies have shown good efficacy, very low cardiovascular side effects and a favourable bleeding pattern, as well as maintenance of ovulation inhibition after scheduled 24 h delays in pill intake.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Contraception and Reproductive Health Care |
Vol/bind | 25 |
Udgave nummer | 3 |
Sider (fra-til) | 221-227 |
Antal sider | 7 |
ISSN | 1362-5187 |
DOI | |
Status | Udgivet - 2020 |
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ID: 261447255