Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with ST-Elevation Myocardial Infarction and Its Association with Acute Kidney Injury and Mortality

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  • Mathias Alexander Højagergaard
  • Rasmus Paulin Beske
  • Hassager, Christian
  • Holmvang, Lene
  • Lisette Okkels Jensen
  • Yacov Shacham
  • Martin Abild Stengaard Meyer
  • Jacob Eifer Moeller
  • Ole Kristian Lerche Helgestad
  • Peter Dall Mark
  • Rasmus Møgelvang
  • Martin Frydland
Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory biomarker related to acute kidney injury (AKI). Including 1892 consecutive patients with ST-elevation myocardial infarction (STEMI), in which NGAL was measured in 1624 (86%) on admission and in a consecutive subgroup at 6–12 h (n = 163) and 12–24 h (n = 222) after admission, this study aimed to evaluate the prognostic value of NGAL in predicting AKI and mortality. Patients were stratified based on whether their admission NGAL plasma concentration was greater than or equal to/less than the median. The primary endpoint was a composite of the first occurrence of AKI or all-cause death within 30 days. AKI was classified by the maximal plasma creatinine increase from baseline during index admission as KDIGO1 (<200% increase) or KDIGO23 (≥200% increase) according to the Kidney Disease Improving Global Outcomes (KDIGO) system. Admission NGAL > the median was independently associated with a higher risk of severe AKI (KDIGO2-3) and 30-day all-cause mortality when adjusted for age, admission systolic blood pressure and high-sensitivity C-reactive protein, left-ventricular ejection fraction, known kidney dysfunction, and cardiogenic shock with an odds ratio (95% confidence interval) of 2.26 (1.18–4.51), p = 0.014. Finally, we observed increasing predictive values in a subgroup during the first day of hospitalization suggesting that assessment of NGAL should be delayed for optimal prognostic purposes.
OriginalsprogEngelsk
Artikelnummer3681
TidsskriftJournal of Clinical Medicine
Vol/bind12
Udgave nummer11
Antal sider12
ISSN2077-0383
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
This work was supported by Righospitalets Forskningsfond (Grant number: 07IO), Forskningspuljen ml RH og OUH [Grant number 13-A750, 25-A1365], The Danish Heart Foundation (Hjerteforeningen) [Grant number A6024], Lundbeck Foundation (R186-2015-2132), and Hjertecentrets Forskningsudvalg, Rigshospitalet [no grant number].

Publisher Copyright:
© 2023 by the authors.

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