Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo

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Standard

Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. / Hundahl, Christian Ansgar; Luuk, Hendrik; Ilmjärv, Sten; Falktoft, Birgitte; Raida, Zindy; Vikesaa, Jonas; Friis-Hansen, Lennart; Hay-Schmidt, Anders.

I: PLOS ONE, Bind 6, Nr. 12, 2011, s. e28160.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hundahl, CA, Luuk, H, Ilmjärv, S, Falktoft, B, Raida, Z, Vikesaa, J, Friis-Hansen, L & Hay-Schmidt, A 2011, 'Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo', PLOS ONE, bind 6, nr. 12, s. e28160. https://doi.org/10.1371/journal.pone.0028160

APA

Hundahl, C. A., Luuk, H., Ilmjärv, S., Falktoft, B., Raida, Z., Vikesaa, J., Friis-Hansen, L., & Hay-Schmidt, A. (2011). Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. PLOS ONE, 6(12), e28160. https://doi.org/10.1371/journal.pone.0028160

Vancouver

Hundahl CA, Luuk H, Ilmjärv S, Falktoft B, Raida Z, Vikesaa J o.a. Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. PLOS ONE. 2011;6(12):e28160. https://doi.org/10.1371/journal.pone.0028160

Author

Hundahl, Christian Ansgar ; Luuk, Hendrik ; Ilmjärv, Sten ; Falktoft, Birgitte ; Raida, Zindy ; Vikesaa, Jonas ; Friis-Hansen, Lennart ; Hay-Schmidt, Anders. / Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo. I: PLOS ONE. 2011 ; Bind 6, Nr. 12. s. e28160.

Bibtex

@article{1ebd4552e7ef4b699097ae7d5b3ffc28,
title = "Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo",
abstract = "Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain. Here we address whether Ngb is required for neuronal survival following acute and prolonged hypoxia in mice genetically Ngb-deficient (Ngb-null). Further, to evaluate whether the lack of Ngb has an effect on hypoxia-dependent gene regulation, we performed a transcriptome-wide analysis of differential gene expression using Affymetrix Mouse Gene 1.0 ST arrays. Differential expression was estimated by a novel data analysis approach, which applies non-parametric statistical inference directly to probe level measurements.",
keywords = "Animals, Anoxia, Brain, Cell Survival, Chromatin, Gene Expression Regulation, Genotype, Globins, Glycolysis, Hypoxia-Inducible Factor 1, alpha Subunit, Immunohistochemistry, Male, Mice, Mice, Transgenic, Models, Biological, Nerve Tissue Proteins, Neurons, Oligonucleotide Array Sequence Analysis, Proto-Oncogene Proteins c-fos",
author = "Hundahl, {Christian Ansgar} and Hendrik Luuk and Sten Ilmj{\"a}rv and Birgitte Falktoft and Zindy Raida and Jonas Vikesaa and Lennart Friis-Hansen and Anders Hay-Schmidt",
year = "2011",
doi = "10.1371/journal.pone.0028160",
language = "English",
volume = "6",
pages = "e28160",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "12",

}

RIS

TY - JOUR

T1 - Neuroglobin-deficiency exacerbates Hif1A and c-FOS response, but does not affect neuronal survival during severe hypoxia in vivo

AU - Hundahl, Christian Ansgar

AU - Luuk, Hendrik

AU - Ilmjärv, Sten

AU - Falktoft, Birgitte

AU - Raida, Zindy

AU - Vikesaa, Jonas

AU - Friis-Hansen, Lennart

AU - Hay-Schmidt, Anders

PY - 2011

Y1 - 2011

N2 - Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain. Here we address whether Ngb is required for neuronal survival following acute and prolonged hypoxia in mice genetically Ngb-deficient (Ngb-null). Further, to evaluate whether the lack of Ngb has an effect on hypoxia-dependent gene regulation, we performed a transcriptome-wide analysis of differential gene expression using Affymetrix Mouse Gene 1.0 ST arrays. Differential expression was estimated by a novel data analysis approach, which applies non-parametric statistical inference directly to probe level measurements.

AB - Neuroglobin (Ngb), a neuron-specific globin that binds oxygen in vitro, has been proposed to play a key role in neuronal survival following hypoxic and ischemic insults in the brain. Here we address whether Ngb is required for neuronal survival following acute and prolonged hypoxia in mice genetically Ngb-deficient (Ngb-null). Further, to evaluate whether the lack of Ngb has an effect on hypoxia-dependent gene regulation, we performed a transcriptome-wide analysis of differential gene expression using Affymetrix Mouse Gene 1.0 ST arrays. Differential expression was estimated by a novel data analysis approach, which applies non-parametric statistical inference directly to probe level measurements.

KW - Animals

KW - Anoxia

KW - Brain

KW - Cell Survival

KW - Chromatin

KW - Gene Expression Regulation

KW - Genotype

KW - Globins

KW - Glycolysis

KW - Hypoxia-Inducible Factor 1, alpha Subunit

KW - Immunohistochemistry

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Models, Biological

KW - Nerve Tissue Proteins

KW - Neurons

KW - Oligonucleotide Array Sequence Analysis

KW - Proto-Oncogene Proteins c-fos

U2 - 10.1371/journal.pone.0028160

DO - 10.1371/journal.pone.0028160

M3 - Journal article

C2 - 22164238

VL - 6

SP - e28160

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 12

ER -

ID: 47927951