TY - JOUR

T1 - Neuroanatomical heterogeneity and homogeneity in individuals at clinical high risk for psychosis

AU - Baldwin, Helen

AU - Radua, Joaquim

AU - Antoniades, Mathilde

AU - Haas, Shalaila S.

AU - Frangou, Sophia

AU - Agartz, Ingrid

AU - Allen, Paul

AU - Andreassen, Ole A.

AU - Atkinson, Kimberley

AU - Bachman, Peter

AU - Baeza, Inmaculada

AU - Bartholomeusz, Cali F.

AU - Chee, Michael W.L.

AU - Colibazzi, Tiziano

AU - Cooper, Rebecca E.

AU - Corcoran, Cheryl M.

AU - Cropley, Vanessa L.

AU - Ebdrup, Bjørn H.

AU - Fortea, Adriana

AU - Glenthøj, Louise Birkedal

AU - Hamilton, Holly K.

AU - Haut, Kristen M.

AU - Hayes, Rebecca A.

AU - He, Ying

AU - Heekeren, Karsten

AU - Kaess, Michael

AU - Kasai, Kiyoto

AU - Katagiri, Naoyuki

AU - Kim, Minah

AU - Kindler, Jochen

AU - Klaunig, Mallory J.

AU - Koike, Shinsuke

AU - Koppel, Alex

AU - Kristensen, Tina D.

AU - Bin Kwak, Yoo

AU - Kwon, Jun Soo

AU - Lawrie, Stephen M.

AU - Lebedeva, Irina

AU - Lee, Jimmy

AU - Lin, Ashleigh

AU - Loewy, Rachel L.

AU - Mathalon, Daniel H.

AU - Michel, Chantal

AU - Mizrahi, Romina

AU - Nordholm, Dorte

AU - Pantelis, Christos

AU - Glenthøj, Birte Yding

AU - Nordentoft, Merete

AU - Sørensen, Mikkel E.

AU - Wenneberg, Christina

AU - the ENIGMA Clinical High Risk for Psychosis Working Group

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the ‘normativeness’ of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.

AB - Individuals at Clinical High Risk for Psychosis (CHR-P) demonstrate heterogeneity in clinical profiles and outcome features. However, the extent of neuroanatomical heterogeneity in the CHR-P state is largely undetermined. We aimed to quantify the neuroanatomical heterogeneity in structural magnetic resonance imaging measures of cortical surface area (SA), cortical thickness (CT), subcortical volume (SV), and intracranial volume (ICV) in CHR-P individuals compared with healthy controls (HC), and in relation to subsequent transition to a first episode of psychosis. The ENIGMA CHR-P consortium applied a harmonised analysis to neuroimaging data across 29 international sites, including 1579 CHR-P individuals and 1243 HC, offering the largest pooled CHR-P neuroimaging dataset to date. Regional heterogeneity was indexed with the Variability Ratio (VR) and Coefficient of Variation (CV) ratio applied at the group level. Personalised estimates of heterogeneity of SA, CT and SV brain profiles were indexed with the novel Person-Based Similarity Index (PBSI), with two complementary applications. First, to assess the extent of within-diagnosis similarity or divergence of neuroanatomical profiles between individuals. Second, using a normative modelling approach, to assess the ‘normativeness’ of neuroanatomical profiles in individuals at CHR-P. CHR-P individuals demonstrated no greater regional heterogeneity after applying FDR corrections. However, PBSI scores indicated significantly greater neuroanatomical divergence in global SA, CT and SV profiles in CHR-P individuals compared with HC. Normative PBSI analysis identified 11 CHR-P individuals (0.70%) with marked deviation (>1.5 SD) in SA, 118 (7.47%) in CT and 161 (10.20%) in SV. Psychosis transition was not significantly associated with any measure of heterogeneity. Overall, our examination of neuroanatomical heterogeneity within the CHR-P state indicated greater divergence in neuroanatomical profiles at an individual level, irrespective of psychosis conversion. Further large-scale investigations are required of those who demonstrate marked deviation.

U2 - 10.1038/s41398-022-02057-y

DO - 10.1038/s41398-022-02057-y

M3 - Journal article

C2 - 35882855

AN - SCOPUS:85135084731

VL - 12

JO - Translational Psychiatry

JF - Translational Psychiatry

SN - 2158-3188

IS - 1

M1 - 297

ER -