Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy. / Følsgaard, Nilofar Vahman; Chawes, Bo Lund Krogsgaard; Rasmussen, Morten Arendt; Bischoff, Anne Louise; Carson, Charlotte G.; Stokholm, Jakob; Pedersen, Louise Lindkvist; Hansel, Trevor T.; Bønnelykke, Klaus; Brix, Susanne; Bisgaard, Hans.
I: American Journal of Respiratory and Critical Care Medicine, Bind 185, Nr. 3, 2012, s. 275-280.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Neonatal Cytokine Profile in the Airway Mucosal Lining Fluid is skewed by Maternal Atopy
AU - Følsgaard, Nilofar Vahman
AU - Chawes, Bo Lund Krogsgaard
AU - Rasmussen, Morten Arendt
AU - Bischoff, Anne Louise
AU - Carson, Charlotte G.
AU - Stokholm, Jakob
AU - Pedersen, Louise Lindkvist
AU - Hansel, Trevor T.
AU - Bønnelykke, Klaus
AU - Brix, Susanne
AU - Bisgaard, Hans
PY - 2012
Y1 - 2012
N2 - Rationale Heredity from mother or father may impact differently in complex diseases such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosa lining fluid of healthy neonates. Objectives We wished to study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosa lining fluid of healthy neonates. Methods 18 cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) birth cohort. Measurements and Main Results Maternal, but not paternal, atopic status (asthma, hay fever and/or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P=0.015). Conclusions Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.
AB - Rationale Heredity from mother or father may impact differently in complex diseases such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosa lining fluid of healthy neonates. Objectives We wished to study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosa lining fluid of healthy neonates. Methods 18 cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) birth cohort. Measurements and Main Results Maternal, but not paternal, atopic status (asthma, hay fever and/or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P=0.015). Conclusions Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.
U2 - 10.1164/rccm.201108-1471OC
DO - 10.1164/rccm.201108-1471OC
M3 - Journal article
C2 - 22077068
VL - 185
SP - 275
EP - 280
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
SN - 1073-449X
IS - 3
ER -
ID: 38081917