Imposed by the Danish Ministry of Higher Education & Science, 100% of research outputs in Denmark should be publicly available starting from 2025. Like many others, University of Copenhagen (UCPH) is subject to a national OA strategy as well as Plan S becoming a reality. These changes impact millions of researchers, and all institutions, publishers, and funders worldwide have to take action to, on the one hand, drive change towards OA and Open Science, and on the other hand, comply with the increasingly enforced policies. At UCPH, around 57% of research outputs are published OA today. In addition, UCPH already spends around 2 M€ per year in APCs ─ a cost that the university cannot afford to increase. The situation is faced with numerous challenges with increasing complexities of different policies from different funders, different research assessment frameworks, different publisher business models as a response, and a great deal of fragmentation due to the lack of collaboration between the stakeholders. UCPH and the Royal Danish Library have therefore partnered with Chronos Hub, a platform and service provider for streamlining publication processes. In this talk, we’ll share our experiences of solving these challenges from an institutional perspective. How did we bridge the communication between institutions, publishers, and funders, to unburden both administrators and the individual researchers? What are the effects? What have we learned? And what are the remaining challenges?