TY - JOUR

T1 - Nasopharyngeal malignancies in Denmark diagnosed from 1980 to 2014

AU - Grønlund, Mathias Peter

AU - Jakobsen, Kathrine Kronberg

AU - Mirian, Christian

AU - Grønhøj, Christian

AU - Juul Nielsen, Kristoffer

AU - Charabi, Birgitte

AU - Lelkaitis, Giedrius

AU - Bentzen, Jens

AU - Von Bucwald, Christian

PY - 2021

Y1 - 2021

N2 - ObjectivesNasopharyngeal malignancies are reported having decreasing incidence and reduced mortality. This study provides a nationwide update of the incidence and survival in Denmark.Materials and methodsThe Danish Cancer Registry (DCR) and Central Population Register (CPR) were used to identify all patients registered with nasopharyngeal malignancies between 1980 and 2014 in Denmark. We evaluated the age-adjusted incidence rate (AAIR), average annual percent change (AAPC) and relative survival (RS) and also constructed age-population-cohort (APC) models.Results911 patients were identified with a male:female ratio of 2.2:1, a median age of 57.7 years (range 2.8–98.3 years) and an overall median follow-up time of 2.7 years (range 0–37 years). The AAIR was 0.39 cases per 100 000 in 1980 and 0.28 cases per 100 000 in 2014 with an AAPC of −3.2 (95% CI: −7.5; 1.2, p = 0.1). The overall 1-year and 5-year RS rates were 76.3% and 42.1%, respectively. We found a significant age effect in the APC model for the incidence of nasopharyngeal malignancies, but no significant cohort or period effects.ConclusionThe incidence of nasopharyngeal carcinomas has slightly decreased over the last four decades, however insignificantly. Meanwhile, the relative survival has increased significantly in Denmark since 1980. The cause of improved relative survival might be attributed to altered treatment practices.

AB - ObjectivesNasopharyngeal malignancies are reported having decreasing incidence and reduced mortality. This study provides a nationwide update of the incidence and survival in Denmark.Materials and methodsThe Danish Cancer Registry (DCR) and Central Population Register (CPR) were used to identify all patients registered with nasopharyngeal malignancies between 1980 and 2014 in Denmark. We evaluated the age-adjusted incidence rate (AAIR), average annual percent change (AAPC) and relative survival (RS) and also constructed age-population-cohort (APC) models.Results911 patients were identified with a male:female ratio of 2.2:1, a median age of 57.7 years (range 2.8–98.3 years) and an overall median follow-up time of 2.7 years (range 0–37 years). The AAIR was 0.39 cases per 100 000 in 1980 and 0.28 cases per 100 000 in 2014 with an AAPC of −3.2 (95% CI: −7.5; 1.2, p = 0.1). The overall 1-year and 5-year RS rates were 76.3% and 42.1%, respectively. We found a significant age effect in the APC model for the incidence of nasopharyngeal malignancies, but no significant cohort or period effects.ConclusionThe incidence of nasopharyngeal carcinomas has slightly decreased over the last four decades, however insignificantly. Meanwhile, the relative survival has increased significantly in Denmark since 1980. The cause of improved relative survival might be attributed to altered treatment practices.

U2 - 10.1016/j.oraloncology.2021.105583

DO - 10.1016/j.oraloncology.2021.105583

M3 - Journal article

C2 - 34695757

VL - 122

JO - Oral Oncology Extra

JF - Oral Oncology Extra

SN - 1741-9409

M1 - 105583

ER -