Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes. / You, Xinxin; Bian, Chao; Zan, Qijie; Xu, Xun; Liu, Xin; Chen, Jieming; Wang, Jintu; Qiu, Ying; Li, Wujiao; Zhang, Xinhui; Sun, Ying; Chen, Shixi; Hong, Wanshu; Li, Yuxiang; Cheng, Shifeng; Fan, Guangyi; Shi, Chengcheng; Liang, Jie; Tom Tang, Y; Yang, Chengye; Ruan, Zhiqiang; Bai, Jie; Peng, Chao; Mu, Qian; Lu, Jun; Fan, Mingjun; Yang, Shuang; Huang, Zhiyong; Jiang, Xuanting; Fang, Xiaodong; Zhang, Guojie; Zhang, Yong; Polgar, Gianluca; Yu, Hui; Li, Jia; Liu, Zhongjian; Zhang, Guoqiang; Ravi, Vydianathan; Coon, Steven L; Wang, Jian; Yang, Huanming; Venkatesh, Byrappa; Wang, Jun; Shi, Qiong.
I: Nature Communications, Bind 5, Nr. 5594, 2014.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Mudskipper genomes provide insights into the terrestrial adaptation of amphibious fishes
AU - You, Xinxin
AU - Bian, Chao
AU - Zan, Qijie
AU - Xu, Xun
AU - Liu, Xin
AU - Chen, Jieming
AU - Wang, Jintu
AU - Qiu, Ying
AU - Li, Wujiao
AU - Zhang, Xinhui
AU - Sun, Ying
AU - Chen, Shixi
AU - Hong, Wanshu
AU - Li, Yuxiang
AU - Cheng, Shifeng
AU - Fan, Guangyi
AU - Shi, Chengcheng
AU - Liang, Jie
AU - Tom Tang, Y
AU - Yang, Chengye
AU - Ruan, Zhiqiang
AU - Bai, Jie
AU - Peng, Chao
AU - Mu, Qian
AU - Lu, Jun
AU - Fan, Mingjun
AU - Yang, Shuang
AU - Huang, Zhiyong
AU - Jiang, Xuanting
AU - Fang, Xiaodong
AU - Zhang, Guojie
AU - Zhang, Yong
AU - Polgar, Gianluca
AU - Yu, Hui
AU - Li, Jia
AU - Liu, Zhongjian
AU - Zhang, Guoqiang
AU - Ravi, Vydianathan
AU - Coon, Steven L
AU - Wang, Jian
AU - Yang, Huanming
AU - Venkatesh, Byrappa
AU - Wang, Jun
AU - Shi, Qiong
PY - 2014
Y1 - 2014
N2 - Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers' tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
AB - Mudskippers are amphibious fishes that have developed morphological and physiological adaptations to match their unique lifestyles. Here we perform whole-genome sequencing of four representative mudskippers to elucidate the molecular mechanisms underlying these adaptations. We discover an expansion of innate immune system genes in the mudskippers that may provide defence against terrestrial pathogens. Several genes of the ammonia excretion pathway in the gills have experienced positive selection, suggesting their important roles in mudskippers' tolerance to environmental ammonia. Some vision-related genes are differentially lost or mutated, illustrating genomic changes associated with aerial vision. Transcriptomic analyses of mudskippers exposed to air highlight regulatory pathways that are up- or down-regulated in response to hypoxia. The present study provides a valuable resource for understanding the molecular mechanisms underlying water-to-land transition of vertebrates.
U2 - 10.1038/ncomms6594
DO - 10.1038/ncomms6594
M3 - Journal article
C2 - 25463417
VL - 5
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
IS - 5594
ER -
ID: 132432103