Monitoring of intense neuromuscular blockade in a pig model
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Monitoring of intense neuromuscular blockade in a pig model. / Madsen, Matias V; Donatsky, Anders M; Jensen, Bente Rona; Rosenberg, Jacob; Hammelev, Karsten P; Gätke, Mona Ring.
I: Journal of Clinical Monitoring and Computing, Bind 28, Nr. 4, 2014, s. 351-355.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Monitoring of intense neuromuscular blockade in a pig model
AU - Madsen, Matias V
AU - Donatsky, Anders M
AU - Jensen, Bente Rona
AU - Rosenberg, Jacob
AU - Hammelev, Karsten P
AU - Gätke, Mona Ring
N1 - CURIS 2014 NEXS 036
PY - 2014
Y1 - 2014
N2 - Intense neuromuscular blockade (NMB) measured by post tetanic count (PTC) was monitored, reversed and verified in this pig model. In a cross-over assessor blinded design six pigs were randomized to either no NMB followed by intense NMB, or intense NMB followed by no NMB. Neuromuscular measurements were performed with acceleromyography [train-of-four (TOF) Watch SX]. In all pigs, the response to TOF nerve stimulation was stable and intense NMB (PTC 0-1) was established with rocuronium 3 mg/kg. For reversal, the pigs received sugammadex 20-35 mg/kg and returned to TOF-ratio above 0.90 within 2.15 min after injection. We established a pig model for monitoring intense NMB with surface stimulation electrodes and acceleromyography. We verified total relaxation of the diaphragm and the abdominal muscles at the PTC 0-1 by suction test and with surface electromyography. This pig model is suitable for studies with experimental abdominal surgery with monitoring of intense NMB, and where relaxation of the diaphragm and the abdominal muscles are required.
AB - Intense neuromuscular blockade (NMB) measured by post tetanic count (PTC) was monitored, reversed and verified in this pig model. In a cross-over assessor blinded design six pigs were randomized to either no NMB followed by intense NMB, or intense NMB followed by no NMB. Neuromuscular measurements were performed with acceleromyography [train-of-four (TOF) Watch SX]. In all pigs, the response to TOF nerve stimulation was stable and intense NMB (PTC 0-1) was established with rocuronium 3 mg/kg. For reversal, the pigs received sugammadex 20-35 mg/kg and returned to TOF-ratio above 0.90 within 2.15 min after injection. We established a pig model for monitoring intense NMB with surface stimulation electrodes and acceleromyography. We verified total relaxation of the diaphragm and the abdominal muscles at the PTC 0-1 by suction test and with surface electromyography. This pig model is suitable for studies with experimental abdominal surgery with monitoring of intense NMB, and where relaxation of the diaphragm and the abdominal muscles are required.
U2 - 10.1007/s10877-013-9539-1
DO - 10.1007/s10877-013-9539-1
M3 - Journal article
C2 - 24306323
VL - 28
SP - 351
EP - 355
JO - Journal of Clinical Monitoring and Computing
JF - Journal of Clinical Monitoring and Computing
SN - 1387-1307
IS - 4
ER -
ID: 91945050