TY - JOUR

T1 - Mixing short- and long-acting local anaesthetics in peripheral nerve blocks

T2 - Protocol for a systematic review and meta-analysis

AU - Temberg, Jens L.

AU - Pisljagic, Sanja

AU - Steensbæk, Mathias T.

AU - Yousef, Sina

AU - Chafranska, Lana

AU - Lange, Kai H.W.

AU - Rothe, Christian

AU - Nørskov, Anders K.

AU - Maagaard, Mathias

AU - Lundstrøm, Lars H.

N1 - Publisher Copyright: © 2023 Acta Anaesthesiologica Scandinavica Foundation.

PY - 2024

Y1 - 2024

N2 - Introduction: This protocol describes a systematic review and meta-analysis to evaluate the clinical effects of mixing short- and long-acting local anaesthetics in peripheral nerve blocks. Clinicians often combine short- and long-acting local anaesthetics to achieve a briefer onset time. However, this may come with a prize, namely a shorter total duration of the block, which is of clinical importance. Objective: This systematic review aims to strengthen the knowledge of the clinical effects associated with this practice. The primary outcome is the duration of block analgesia. Secondary outcomes are block onset time, sensory and motor block duration. Exploratory outcomes are postoperative pain scores, cumulative 24-h opioid consumption and the prevalence of serious adverse events. Methods: We will conduct a meta-analysis of the extracted data, and the risk of bias for each study will be evaluated. We will perform a Trial Sequential Analysis, subgroup, and sensitivity analyses and assess the overall risk of publication bias. Finally, we will evaluate the review using the GRADE principles.

AB - Introduction: This protocol describes a systematic review and meta-analysis to evaluate the clinical effects of mixing short- and long-acting local anaesthetics in peripheral nerve blocks. Clinicians often combine short- and long-acting local anaesthetics to achieve a briefer onset time. However, this may come with a prize, namely a shorter total duration of the block, which is of clinical importance. Objective: This systematic review aims to strengthen the knowledge of the clinical effects associated with this practice. The primary outcome is the duration of block analgesia. Secondary outcomes are block onset time, sensory and motor block duration. Exploratory outcomes are postoperative pain scores, cumulative 24-h opioid consumption and the prevalence of serious adverse events. Methods: We will conduct a meta-analysis of the extracted data, and the risk of bias for each study will be evaluated. We will perform a Trial Sequential Analysis, subgroup, and sensitivity analyses and assess the overall risk of publication bias. Finally, we will evaluate the review using the GRADE principles.

KW - local anaesthetic combination

KW - local anaesthetic mixture

KW - nerve block duration

KW - peripheral nerve block

KW - regional anaesthesia

U2 - 10.1111/aas.14352

DO - 10.1111/aas.14352

M3 - Review

C2 - 37947347

AN - SCOPUS:85176547961

VL - 68

SP - 417

EP - 422

JO - Acta Anaesthesiologica Scandinavica

JF - Acta Anaesthesiologica Scandinavica

SN - 0001-5172

IS - 3

ER -