Metabolic syndrome, soluble CD40L, and biomarkers of endothelial dysfunction in people living with HIV
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Metabolic syndrome, soluble CD40L, and biomarkers of endothelial dysfunction in people living with HIV. / Jacobsen, Mads Holger B.; Knudsen, Andreas D.; Benfield, Thomas; Ostrowski, Sisse R.; Afzal, Shoaib; Sørensen, Edith W.; Nielsen, Susanne D.; Gelpi, Marco.
I: APMIS, Bind 131, Nr. 12, 2023, s. 705-709.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Metabolic syndrome, soluble CD40L, and biomarkers of endothelial dysfunction in people living with HIV
AU - Jacobsen, Mads Holger B.
AU - Knudsen, Andreas D.
AU - Benfield, Thomas
AU - Ostrowski, Sisse R.
AU - Afzal, Shoaib
AU - Sørensen, Edith W.
AU - Nielsen, Susanne D.
AU - Gelpi, Marco
N1 - Publisher Copyright: © 2023 The Authors. APMIS published by John Wiley & Sons Ltd on behalf of Scandinavian Societies for Pathology, Medical Microbiology and Immunology.
PY - 2023
Y1 - 2023
N2 - In the present study, we aimed to investigate the association between soluble CD40 ligand (sCD40L, a marker of platelet activation), soluble thrombomodulin, and syndecan-1 (both well-described markers of endothelial dysfunction) and metabolic syndrome in a large cohort of well-treated people with HIV (PWH) and to elucidate their association with HIV-specific variables. We included 862 PWH with undetectable viral replication. Our hypotheses were tested using uni- and multivariable logistic regression models a priori adjusted for well-known confounders. While no association of soluble thrombomodulin and syndecan-1 with MetS was found, high levels of sCD40L (aOR 1.54 [1.07–2.22]) were associated with excess risk of MetS. Given the previously described association between sCD40L, vascular inflammation and endothelial damage, the results presented in our study may suggest a potential role for sCD40L in the well-known association between cardiometabolic comorbidity and HIV infection.
AB - In the present study, we aimed to investigate the association between soluble CD40 ligand (sCD40L, a marker of platelet activation), soluble thrombomodulin, and syndecan-1 (both well-described markers of endothelial dysfunction) and metabolic syndrome in a large cohort of well-treated people with HIV (PWH) and to elucidate their association with HIV-specific variables. We included 862 PWH with undetectable viral replication. Our hypotheses were tested using uni- and multivariable logistic regression models a priori adjusted for well-known confounders. While no association of soluble thrombomodulin and syndecan-1 with MetS was found, high levels of sCD40L (aOR 1.54 [1.07–2.22]) were associated with excess risk of MetS. Given the previously described association between sCD40L, vascular inflammation and endothelial damage, the results presented in our study may suggest a potential role for sCD40L in the well-known association between cardiometabolic comorbidity and HIV infection.
KW - cardiometabolic disease
KW - endotelial dysfunction
KW - HIV
KW - inflammation
KW - metabolic syndrome
KW - soluble CD40L
U2 - 10.1111/apm.13354
DO - 10.1111/apm.13354
M3 - Journal article
C2 - 37849049
AN - SCOPUS:85174268603
VL - 131
SP - 705
EP - 709
JO - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
JF - A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica
SN - 0903-4641
IS - 12
ER -
ID: 373976125