Membrane Binding and Modulation of the PDZ Domain of PICK1
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Scaffolding proteins serve to assemble protein complexes in dynamic processes by means of specific protein-protein and protein-lipid binding domains. Many of these domains bind either proteins or lipids exclusively; however, it has become increasingly evident that certain domains are capable of binding both. Especially, many PDZ domains, which are highly abundant protein-protein binding domains, bind lipids and membranes. Here we provide an overview of recent large-scale studies trying to generalize and rationalize the binding patterns as well as specificity of PDZ domains towards membrane lipids. Moreover, we review how these PDZ-membrane interactions are regulated in the case of the synaptic scaffolding protein PICK1 and how this might affect cellular localization and function.
Originalsprog | Engelsk |
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Tidsskrift | Membranes |
Vol/bind | 5 |
Udgave nummer | 4 |
Sider (fra-til) | 597-615 |
Antal sider | 19 |
ISSN | 2077-0375 |
DOI | |
Status | Udgivet - dec. 2015 |
ID: 160923949