Maternal age and the risk of fetal aneuploidy: A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Maternal age and the risk of fetal aneuploidy : A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017. / Elmerdahl Frederiksen, Line; Ølgaard, Sofie Møller; Roos, Laura; Petersen, Olav Bjørn; Rode, Line; Hartwig, Tanja; Ekelund, Charlotte Kvist; Vogel, Ida.
I: Acta Obstetricia et Gynecologica Scandinavica, Bind 103, Nr. 2, 2024, s. 351-359.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Maternal age and the risk of fetal aneuploidy
T2 - A nationwide cohort study of more than 500 000 singleton pregnancies in Denmark from 2008 to 2017
AU - Elmerdahl Frederiksen, Line
AU - Ølgaard, Sofie Møller
AU - Roos, Laura
AU - Petersen, Olav Bjørn
AU - Rode, Line
AU - Hartwig, Tanja
AU - Ekelund, Charlotte Kvist
AU - Vogel, Ida
N1 - Publisher Copyright: © 2023 The Authors. Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG).
PY - 2024
Y1 - 2024
N2 - Introduction: In this register-based study of pregnancies in Denmark, we assessed the associations between maternal age and the risk of fetal aneuploidies (trisomy 21, trisomy 18, trisomy 13, triploidy, monosomy X and other sex chromosome aberrations). Additionally, we aimed to disentangle the maternal age-related effect on fetal aneuploidies by cases with translocation trisomies and mosaicisms. Material and methods: We followed a nationwide cohort of 542 375 singleton-pregnant women attending first trimester screening in Denmark between 2008 and 2017 until delivery, miscarriage or termination of pregnancy. We used six maternal age categories and retrieved information on genetically confirmed aneuploidies of the fetus and infant from the national cytogenetic register. Results: We confirmed the known associations between advanced maternal age and higher risk of trisomy 21, 18, 13 and other sex chromosome aberrations, especially in women aged ≥35 years, whereas we found no age-related associations with triploidy or monosomy X. Cases with translocation trisomies and mosaicisms did not influence the overall reported association between maternal age and aneuploidies. Conclusion: This study provides insight into the accurate risk of fetal aneuploidies that pregnant women of advanced ages encounter.
AB - Introduction: In this register-based study of pregnancies in Denmark, we assessed the associations between maternal age and the risk of fetal aneuploidies (trisomy 21, trisomy 18, trisomy 13, triploidy, monosomy X and other sex chromosome aberrations). Additionally, we aimed to disentangle the maternal age-related effect on fetal aneuploidies by cases with translocation trisomies and mosaicisms. Material and methods: We followed a nationwide cohort of 542 375 singleton-pregnant women attending first trimester screening in Denmark between 2008 and 2017 until delivery, miscarriage or termination of pregnancy. We used six maternal age categories and retrieved information on genetically confirmed aneuploidies of the fetus and infant from the national cytogenetic register. Results: We confirmed the known associations between advanced maternal age and higher risk of trisomy 21, 18, 13 and other sex chromosome aberrations, especially in women aged ≥35 years, whereas we found no age-related associations with triploidy or monosomy X. Cases with translocation trisomies and mosaicisms did not influence the overall reported association between maternal age and aneuploidies. Conclusion: This study provides insight into the accurate risk of fetal aneuploidies that pregnant women of advanced ages encounter.
KW - aneuploidy
KW - genetic risk factors
KW - maternal age
KW - numeric chromosomal anomalies
KW - pregnancy risk
KW - sex chromosome aberrations
KW - triploidy
KW - trisomy
U2 - 10.1111/aogs.14713
DO - 10.1111/aogs.14713
M3 - Journal article
C2 - 37986093
AN - SCOPUS:85177186728
VL - 103
SP - 351
EP - 359
JO - Acta Obstetricia et Gynecologica Scandinavica
JF - Acta Obstetricia et Gynecologica Scandinavica
SN - 0001-6349
IS - 2
ER -
ID: 381681803