Marked reduction in fertility among African women with urogenital infections: A prospective cohort study

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Marked reduction in fertility among African women with urogenital infections : A prospective cohort study. / Perslev, K.; Msemo, O. A.; Minja, D. T. R.; Møller, S. L.; Theander, T. G.; Lusingu, J. P. A.; Bygbjerg, I. C.; Nielsen, B. B.; Schmiegelow, C.

I: PLoS ONE, Bind 14, Nr. 1, e0210421, 2019.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Perslev, K, Msemo, OA, Minja, DTR, Møller, SL, Theander, TG, Lusingu, JPA, Bygbjerg, IC, Nielsen, BB & Schmiegelow, C 2019, 'Marked reduction in fertility among African women with urogenital infections: A prospective cohort study', PLoS ONE, bind 14, nr. 1, e0210421. https://doi.org/10.1371/journal.pone.0210421

APA

Perslev, K., Msemo, O. A., Minja, D. T. R., Møller, S. L., Theander, T. G., Lusingu, J. P. A., ... Schmiegelow, C. (2019). Marked reduction in fertility among African women with urogenital infections: A prospective cohort study. PLoS ONE, 14(1), [e0210421]. https://doi.org/10.1371/journal.pone.0210421

Vancouver

Perslev K, Msemo OA, Minja DTR, Møller SL, Theander TG, Lusingu JPA o.a. Marked reduction in fertility among African women with urogenital infections: A prospective cohort study. PLoS ONE. 2019;14(1). e0210421. https://doi.org/10.1371/journal.pone.0210421

Author

Perslev, K. ; Msemo, O. A. ; Minja, D. T. R. ; Møller, S. L. ; Theander, T. G. ; Lusingu, J. P. A. ; Bygbjerg, I. C. ; Nielsen, B. B. ; Schmiegelow, C. / Marked reduction in fertility among African women with urogenital infections : A prospective cohort study. I: PLoS ONE. 2019 ; Bind 14, Nr. 1.

Bibtex

@article{7b677add8ee945848cfeb1b30d1b2a23,
title = "Marked reduction in fertility among African women with urogenital infections: A prospective cohort study",
abstract = "BackgroundThere is paucity of data on risk factors for reduced fertility in low-income countries.ObjectiveTo investigate factors associated with fertility among women in rural north eastern Tanzania.Subjects and methodsA cohort of 1248 non-pregnant women was followed with urine pregnancy testing every third month or more regularly if they reported a missed menstrual period. Pregnancy was confirmed with trans-abdominal ultrasound. Information regarding general health, socioeconomic status and obstetric-gynaecological history was collected. Factors associated with conceiving within 180 days were identified using multivariate logistic regression analyses.ResultsAmong the 1248 women, 736 were followed for 180 days and 209 of these had an ultrasound confirmed pregnancy. During the follow-up period, 169/736 women were diagnosed with urogenital infections, including suspected sexually transmitted or reproductive tract infections, urinary tract infection, and vaginal candidiasis. Urogenital infections were significantly associated with reduced odds of conceiving within 180 days (adjusted OR (AOR) 0.21, 95{\%} CI 0.11–0.36). Being above 30 years of age was also negatively associated with odds of conceiving (AOR 0.45, 95{\%} CI 0.26–0.77). In contrast, women who recently stopped using hormonal contraceptives (AOR 2.86, 95{\%} CI 1.45–5.70) and women with low socioeconomic status (AOR 1.56, 95{\%} CI 1.04–2.33) were significantly more likely to become pregnant within 180 days.ConclusionUrogenital infection seems to be a major health factor associated with reduced chances of conceiving. Considering the availability of effective treatment options for these diseases, public health authorities should increase awareness of diagnostic tools in settings with limited resources in order to improve fertility.",
author = "K. Perslev and Msemo, {O. A.} and Minja, {D. T. R.} and M{\o}ller, {S. L.} and Theander, {T. G.} and Lusingu, {J. P. A.} and Bygbjerg, {I. C.} and Nielsen, {B. B.} and C. Schmiegelow",
year = "2019",
doi = "10.1371/journal.pone.0210421",
language = "English",
volume = "14",
journal = "P L o S One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Marked reduction in fertility among African women with urogenital infections

T2 - A prospective cohort study

AU - Perslev, K.

AU - Msemo, O. A.

AU - Minja, D. T. R.

AU - Møller, S. L.

AU - Theander, T. G.

AU - Lusingu, J. P. A.

AU - Bygbjerg, I. C.

AU - Nielsen, B. B.

AU - Schmiegelow, C.

PY - 2019

Y1 - 2019

N2 - BackgroundThere is paucity of data on risk factors for reduced fertility in low-income countries.ObjectiveTo investigate factors associated with fertility among women in rural north eastern Tanzania.Subjects and methodsA cohort of 1248 non-pregnant women was followed with urine pregnancy testing every third month or more regularly if they reported a missed menstrual period. Pregnancy was confirmed with trans-abdominal ultrasound. Information regarding general health, socioeconomic status and obstetric-gynaecological history was collected. Factors associated with conceiving within 180 days were identified using multivariate logistic regression analyses.ResultsAmong the 1248 women, 736 were followed for 180 days and 209 of these had an ultrasound confirmed pregnancy. During the follow-up period, 169/736 women were diagnosed with urogenital infections, including suspected sexually transmitted or reproductive tract infections, urinary tract infection, and vaginal candidiasis. Urogenital infections were significantly associated with reduced odds of conceiving within 180 days (adjusted OR (AOR) 0.21, 95% CI 0.11–0.36). Being above 30 years of age was also negatively associated with odds of conceiving (AOR 0.45, 95% CI 0.26–0.77). In contrast, women who recently stopped using hormonal contraceptives (AOR 2.86, 95% CI 1.45–5.70) and women with low socioeconomic status (AOR 1.56, 95% CI 1.04–2.33) were significantly more likely to become pregnant within 180 days.ConclusionUrogenital infection seems to be a major health factor associated with reduced chances of conceiving. Considering the availability of effective treatment options for these diseases, public health authorities should increase awareness of diagnostic tools in settings with limited resources in order to improve fertility.

AB - BackgroundThere is paucity of data on risk factors for reduced fertility in low-income countries.ObjectiveTo investigate factors associated with fertility among women in rural north eastern Tanzania.Subjects and methodsA cohort of 1248 non-pregnant women was followed with urine pregnancy testing every third month or more regularly if they reported a missed menstrual period. Pregnancy was confirmed with trans-abdominal ultrasound. Information regarding general health, socioeconomic status and obstetric-gynaecological history was collected. Factors associated with conceiving within 180 days were identified using multivariate logistic regression analyses.ResultsAmong the 1248 women, 736 were followed for 180 days and 209 of these had an ultrasound confirmed pregnancy. During the follow-up period, 169/736 women were diagnosed with urogenital infections, including suspected sexually transmitted or reproductive tract infections, urinary tract infection, and vaginal candidiasis. Urogenital infections were significantly associated with reduced odds of conceiving within 180 days (adjusted OR (AOR) 0.21, 95% CI 0.11–0.36). Being above 30 years of age was also negatively associated with odds of conceiving (AOR 0.45, 95% CI 0.26–0.77). In contrast, women who recently stopped using hormonal contraceptives (AOR 2.86, 95% CI 1.45–5.70) and women with low socioeconomic status (AOR 1.56, 95% CI 1.04–2.33) were significantly more likely to become pregnant within 180 days.ConclusionUrogenital infection seems to be a major health factor associated with reduced chances of conceiving. Considering the availability of effective treatment options for these diseases, public health authorities should increase awareness of diagnostic tools in settings with limited resources in order to improve fertility.

U2 - 10.1371/journal.pone.0210421

DO - 10.1371/journal.pone.0210421

M3 - Journal article

C2 - 30629655

VL - 14

JO - P L o S One

JF - P L o S One

SN - 1932-6203

IS - 1

M1 - e0210421

ER -

ID: 212293881