Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy

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Standard

Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy. / Mcfadden, Ryan M. L.; Szunyogh, Dániel; Bravo-frank, Nicholas; Chatzichristos, Aris; Dehn, Martin H.; Fujimoto, Derek; Jancsó, Attila; Johannsen, Silke; Kálomista, Ildikó; Karner, Victoria L.; Kiefl, Robert F.; Larsen, Flemming H.; Lassen, Jens; Levy, C. D. Philip; Li, Ruohong; Mckenzie, Iain; Mcphee, Hannah; Morris, Gerald D.; Pearson, Matthew R.; Sauer, Stephan P. A.; Sigel, Roland K. O.; Thulstrup, Peter W.; Macfarlane, W. Andrew; Hemmingsen, Lars; Stachura, Monika.

I: Angewandte Chemie International Edition, Bind 61, Nr. 35, e202207137, 26.08.2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mcfadden, RML, Szunyogh, D, Bravo-frank, N, Chatzichristos, A, Dehn, MH, Fujimoto, D, Jancsó, A, Johannsen, S, Kálomista, I, Karner, VL, Kiefl, RF, Larsen, FH, Lassen, J, Levy, CDP, Li, R, Mckenzie, I, Mcphee, H, Morris, GD, Pearson, MR, Sauer, SPA, Sigel, RKO, Thulstrup, PW, Macfarlane, WA, Hemmingsen, L & Stachura, M 2022, 'Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy', Angewandte Chemie International Edition, bind 61, nr. 35, e202207137. https://doi.org/10.1002/anie.202207137

APA

Mcfadden, R. M. L., Szunyogh, D., Bravo-frank, N., Chatzichristos, A., Dehn, M. H., Fujimoto, D., Jancsó, A., Johannsen, S., Kálomista, I., Karner, V. L., Kiefl, R. F., Larsen, F. H., Lassen, J., Levy, C. D. P., Li, R., Mckenzie, I., Mcphee, H., Morris, G. D., Pearson, M. R., ... Stachura, M. (2022). Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy. Angewandte Chemie International Edition, 61(35), [e202207137]. https://doi.org/10.1002/anie.202207137

Vancouver

Mcfadden RML, Szunyogh D, Bravo-frank N, Chatzichristos A, Dehn MH, Fujimoto D o.a. Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy. Angewandte Chemie International Edition. 2022 aug. 26;61(35). e202207137. https://doi.org/10.1002/anie.202207137

Author

Mcfadden, Ryan M. L. ; Szunyogh, Dániel ; Bravo-frank, Nicholas ; Chatzichristos, Aris ; Dehn, Martin H. ; Fujimoto, Derek ; Jancsó, Attila ; Johannsen, Silke ; Kálomista, Ildikó ; Karner, Victoria L. ; Kiefl, Robert F. ; Larsen, Flemming H. ; Lassen, Jens ; Levy, C. D. Philip ; Li, Ruohong ; Mckenzie, Iain ; Mcphee, Hannah ; Morris, Gerald D. ; Pearson, Matthew R. ; Sauer, Stephan P. A. ; Sigel, Roland K. O. ; Thulstrup, Peter W. ; Macfarlane, W. Andrew ; Hemmingsen, Lars ; Stachura, Monika. / Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy. I: Angewandte Chemie International Edition. 2022 ; Bind 61, Nr. 35.

Bibtex

@article{f055ff814bfc4f08ae6b2aac8067cf7d,
title = "Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy",
abstract = "The complexation of MgII with adenosine 5′-triphosphate (ATP) is omnipresent in biochemical energy conversion, but is difficult to interrogate directly. Here we use the spin-urn:x-wiley:14337851:media:anie202207137:anie202207137-math-0001 β-emitter 31Mg to study MgII-ATP complexation in 1-ethyl-3-methylimidazolium acetate (EMIM-Ac) solutions using β-radiation-detected nuclear magnetic resonance (β-NMR). We demonstrate that (nuclear) spin-polarized 31Mg, following ion-implantation from an accelerator beamline into EMIM-Ac, binds to ATP within its radioactive lifetime before depolarizing. The evolution of the spectra with solute concentration indicates that the implanted 31Mg initially bind to the solvent acetate anions, whereafter they undergo dynamic exchange and form either a mono- (31Mg-ATP) or di-nuclear (31MgMg-ATP) complex. The chemical shift of 31Mg-ATP is observed up-field of 31MgMg-ATP, in accord with quantum chemical calculations. These observations constitute a crucial advance towards using β-NMR to probe chemistry and biochemistry in solution.",
author = "Mcfadden, {Ryan M. L.} and D{\'a}niel Szunyogh and Nicholas Bravo-frank and Aris Chatzichristos and Dehn, {Martin H.} and Derek Fujimoto and Attila Jancs{\'o} and Silke Johannsen and Ildik{\'o} K{\'a}lomista and Karner, {Victoria L.} and Kiefl, {Robert F.} and Larsen, {Flemming H.} and Jens Lassen and Levy, {C. D. Philip} and Ruohong Li and Iain Mckenzie and Hannah Mcphee and Morris, {Gerald D.} and Pearson, {Matthew R.} and Sauer, {Stephan P. A.} and Sigel, {Roland K. O.} and Thulstrup, {Peter W.} and Macfarlane, {W. Andrew} and Lars Hemmingsen and Monika Stachura",
year = "2022",
month = aug,
day = "26",
doi = "10.1002/anie.202207137",
language = "English",
volume = "61",
journal = "Angewandte Chemie International Edition",
issn = "1433-7851",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "35",

}

RIS

TY - JOUR

T1 - Magnesium(II)‐ATP Complexes in 1‐Ethyl‐3‐Methylimidazolium Acetate Solutions Characterized by 31Mg β‐Radiation‐Detected NMR Spectroscopy

AU - Mcfadden, Ryan M. L.

AU - Szunyogh, Dániel

AU - Bravo-frank, Nicholas

AU - Chatzichristos, Aris

AU - Dehn, Martin H.

AU - Fujimoto, Derek

AU - Jancsó, Attila

AU - Johannsen, Silke

AU - Kálomista, Ildikó

AU - Karner, Victoria L.

AU - Kiefl, Robert F.

AU - Larsen, Flemming H.

AU - Lassen, Jens

AU - Levy, C. D. Philip

AU - Li, Ruohong

AU - Mckenzie, Iain

AU - Mcphee, Hannah

AU - Morris, Gerald D.

AU - Pearson, Matthew R.

AU - Sauer, Stephan P. A.

AU - Sigel, Roland K. O.

AU - Thulstrup, Peter W.

AU - Macfarlane, W. Andrew

AU - Hemmingsen, Lars

AU - Stachura, Monika

PY - 2022/8/26

Y1 - 2022/8/26

N2 - The complexation of MgII with adenosine 5′-triphosphate (ATP) is omnipresent in biochemical energy conversion, but is difficult to interrogate directly. Here we use the spin-urn:x-wiley:14337851:media:anie202207137:anie202207137-math-0001 β-emitter 31Mg to study MgII-ATP complexation in 1-ethyl-3-methylimidazolium acetate (EMIM-Ac) solutions using β-radiation-detected nuclear magnetic resonance (β-NMR). We demonstrate that (nuclear) spin-polarized 31Mg, following ion-implantation from an accelerator beamline into EMIM-Ac, binds to ATP within its radioactive lifetime before depolarizing. The evolution of the spectra with solute concentration indicates that the implanted 31Mg initially bind to the solvent acetate anions, whereafter they undergo dynamic exchange and form either a mono- (31Mg-ATP) or di-nuclear (31MgMg-ATP) complex. The chemical shift of 31Mg-ATP is observed up-field of 31MgMg-ATP, in accord with quantum chemical calculations. These observations constitute a crucial advance towards using β-NMR to probe chemistry and biochemistry in solution.

AB - The complexation of MgII with adenosine 5′-triphosphate (ATP) is omnipresent in biochemical energy conversion, but is difficult to interrogate directly. Here we use the spin-urn:x-wiley:14337851:media:anie202207137:anie202207137-math-0001 β-emitter 31Mg to study MgII-ATP complexation in 1-ethyl-3-methylimidazolium acetate (EMIM-Ac) solutions using β-radiation-detected nuclear magnetic resonance (β-NMR). We demonstrate that (nuclear) spin-polarized 31Mg, following ion-implantation from an accelerator beamline into EMIM-Ac, binds to ATP within its radioactive lifetime before depolarizing. The evolution of the spectra with solute concentration indicates that the implanted 31Mg initially bind to the solvent acetate anions, whereafter they undergo dynamic exchange and form either a mono- (31Mg-ATP) or di-nuclear (31MgMg-ATP) complex. The chemical shift of 31Mg-ATP is observed up-field of 31MgMg-ATP, in accord with quantum chemical calculations. These observations constitute a crucial advance towards using β-NMR to probe chemistry and biochemistry in solution.

U2 - 10.1002/anie.202207137

DO - 10.1002/anie.202207137

M3 - Journal article

C2 - 35718746

VL - 61

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

SN - 1433-7851

IS - 35

M1 - e202207137

ER -

ID: 312698439