MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
The selection of pharmacotherapy for patients with allergic rhinitis (AR) depends on several factors, including age, prominent symptoms, symptom severity, control of AR, patient preferences, and cost. Allergen exposure and the resulting symptoms vary, and treatment adjustment is required. Clinical decision support systems (CDSSs) might be beneficial for the assessment of disease control. CDSSs should be based on the best evidence and algorithms to aid patients and health care professionals to jointly determine treatment and its step-up or step-down strategy depending on AR control. Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR [fighting chronic diseases for active and healthy ageing]), one of the reference sites of the European Innovation Partnership on Active and Healthy Ageing, has initiated an allergy sentinel network (the MACVIA-ARIA Sentinel Network). A CDSS is currently being developed to optimize AR control. An algorithm developed by consensus is presented in this article. This algorithm should be confirmed by appropriate trials.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Allergy and Clinical Immunology |
Vol/bind | 138 |
Udgave nummer | 2 |
Sider (fra-til) | 367-374.e2 |
ISSN | 0091-6749 |
DOI | |
Status | Udgivet - 2016 |
Bibliografisk note
Funding Information:
Disclosure of potential conflict of interest: J. Bousquet has received consulting fees from Actelion, Almirall, Meda, Merck, Merck Sharp Dohme, Novartis, Sanofi-Aventis, Takeda, Teva, and Uriach; has received fees for participation in review activities from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach; has received lecture fees from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach; and has received payment for development of educational presentations from Almirall, AstraZeneca, Chiesi, GlaxoSmithKline, Meda, Merck, Merck Sharp Dohme, Novartis, OM Pharma, Sanofi-Aventis, Schering-Plough, Takeda, Teva, and Uriach. K.-C. Bergmann has received lecture fees from Novartis. S. Bosnic-Anticevich is a member of the Teva Pharmaceuticals Devices International Key Experts Panel, has received research support from Research in Real Life, and has received lecture fees and payment for developing educational presentations from Teva and Mundipharma. G. W. Canonica is on the Board for and has received consultancy and lecture fees from ALK-Abelló, Allergopharma, Allergy Therapeutics, Anallergo, Hal, Lofarma, Stallergenes, and Thermo Fisher. T. B. Casale is Executive Vice President of the American Academy of Allergy, Asthma & Immunology (AAAAI). L. Cox has received consultancy fees from Genentech and Allergopharma; has received fees for participation in review activities from Circassia and Biomay; is on the ABAI Board; was on the AAAAI Board; and has received lecture fees from several regional, local, and state allergy meetings. A. A. Cruz is on the Meda Pharma Board, has received research support from GlaxoSmithKline, and has received lecture fees and travel support from Meda. R. Dahl has received lecture fees from Boehringer Ingelheim, AstraZeneca, GlaxoSmithKline, ALK-Abelló, Cipla, Novartis, Meda, and Chiesi. G. De Carlo has received research support from Sanofi Pasteur MSD, Boehringer Ingelheim International, ALK-Abelló, Almirall, Stallergenes France, Air Liquide Sante International, Novartis, GlaxoSmithKline, Mundipharma, and Chiesi. P. Demoly has received consultancy fees from ALK-Abelló, Circassia, Stallergenes, ThermoFisher Scientific, DBV, and Chiesi and has received lecture fees from Menarini, AstraZeneca, GlaxoSmithKline, Allergopharma, and MSD. P. Devillier is on the Meda Pharma Board; has received consultancy fees from Stallergenes, ALK-Abelló, and GlaxoSmithKline; has received lecture fees from Stallergenes and ALK-Abelló; has received payment for manuscript preparation from Stallergenes; and has received travel support from Stallergenes and Meda. M. Fletcher has received consultancy fees from AstraZeneca, Boehringer Ingelheim, Napp, and Teva and has received lecture fees from AstraZeneca, Boehringer Ingelheim, Napp, Novartis, and Teva. W. J. Fokkens has received research support from Meda and has received payment for developing a webcast on treatment of rhinitis for general practitioners. J. Fonseca is on the Boehringer Ingelheim and Novartis Boards; has received consultancy fees from Novartis; has received research support from Fundação Ciência e Tecnologia and Fundação Calouste Gulbenkian; has received lecture fees from AstraZeneca, Aerocrine, Menarini, GlaxoSmithKline, MSD, and Vitoria; and has received travel support from AstraZeneca and Novartis. T. Keil has received research support from the European Union projects MeDALL and iFAAM. P. Kuna has received lecture fees from Adamed, Allergopharma, Almirall, AstraZeneca, GlaxoSmithKline, Hal, Meda, Pfizer, Polpharma, Stallergenes, Lekam, and Bayer and has received lecture fees and is on the advisory board from Boehringer Ingelheim, Celon Pharma, Chiesi, FAES, MSD, Novartis, Polpharma, and Teva. D. Larenas-Linnemann has received consultancy fees from Boehringer Ingelheim, Meda, Pfizer, Mit Pharma, and Chiesi; has received research support from AstraZeneca, MSD, Novartis, Sanofi, UCB, GlaxoSmithKline, Pfizer, MEDA, TEVA, Senosiain, Carnot; has received lecture fees from AstraZeneca, MSD, Movartis, Sanofi, Pfizer, and Meda; has received payment for development of educational presentations from Glenmark; and has received travel support from ALK-Abelló. K. C. Lodrup Carlsen has received research and travel support from EU MedALL, is on the Sanofi advisory board, has received research support from National and regional public funding applications. E. O. Meltzer has received consultancy fees from AstraZeneca, Boehringer Ingelheim, Church & Dwight, GlaxoSmithKline, Greer, Johnson & Johnson, Meda, Mylan, Regeneron/Sanofi, and Teva; is self-employed; has received lecture fees from Greer, Meda, Merck, Mylan, Takeda, and Teva; and has received payment for developing educational presentations from Glenmark. J. Mullol is on the boards for Uriach, Meda, FAES, ALK-Abelló, and Sanofi; has received research support from GlaxoSmithKline, Uriach, FAES, and Meda; and has received lecture fees from Uriach, Hartington Pharmaceuticals, Novartis, FAES, Menarini, MSD, Pierre-Fabre, and UCB. A. Muraro has received consultancy fees from Meda. R. N. Naclerio is on the Merck and Sanofi allergy advisory boards, has received consultancy fees from Teva, is employed by the University of Chicago, and has received research support from Meda. S. Palkonen is on the GlaxoSmithKline European Health Advisory Board; has received research support from Air Liquide Sante International, ALK-Abelló, Almirall, Boehringer Ingelheim, GlaxoSmithKline, Novartis, Chiesi, Mundipharma, Sanofi-Pasteur, and Stallergenes; has received travel support from Novartis; and declares that she regularly has dialogue with the funding partners listed above, who give unrestricted educational grants to the patient organization, EFA, for which she works as a Director. N. Papadopoulos has received research support from GlaxoSmithKline, Nestle, and Merck; has received payment for developing educational presentations from Abbvie, Sanofi, Menarini, and Meda; has received consultancy fees from GlaxoSmithKline, Abbvie, Novartis, Menarini, Meda, and ALK-Abelló; and has received lecture fees from Allergopharma, Uriach, GlaxoSmithKline, Stallergenes, and MSD. D. Price is on the boards for Aerocrine, Almirall, Amgen, AstraZeneca, Boehringer Ingelheim, Chiesi, Meda, Mundipharma, Napp, Novartis, and Teva; has received consultancy fees from Almirall, Amgen, AstraZeneca, Boehringer Ingelheim, Chiesi, GlaxoSmithKline, Meda, Mundipharma, Napp, Novartis, Pfizer, and Teva; has received research support from the UK National Health Service, British Lung Foundation, Aerocrine, AKL Ltd, Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Eli Lilly, GlaxoSmithKline, Meda, Merck, Mundipharma, Napp, Novartis, Orion, Pfizer, Respiratory Effectiveness Group, Takeda, Teva, Zentiva; has received lecture fees from Almirall, AstraZeneca, Boehringer Ingelheim, Chiesi, Cipla, GlaxoSmithKline, Kyorin, Meda, Merck, Mundipharma, Novartis, Pfizer, SkyePharma, Takeda, and Teva; has received payment for manuscript preparation from Mundipharma and Teva; has a patent with AKL Ltd; has received payment for developing educational presentations from GlaxoSmithKline and Novartis; has stock in AKL Ltd; has received travel support from Aerocrine, Boehringer Ingelheim, Mundipharma, Napp, Novartis, and Teva; has received funding for patient enrolment or completion of research from Almirall, Chiesi, Teva, and Zentiva; has served as a peer reviewer for grant committees for the Medical Research Council, Efficacy and Mechanism Evaluation Programme, and HTA; and is 80% owner of Research in Real Life, which receives unrestricted funding for investigator-initiated studies from Aerocrine, AKL Ltd, Almirall, Boehringer Ingelheim, Chiesi, Meda, Mundipharma, Napp, Novartis, Orion, Takeda, Teva, and Zentiva. D. Ryan is on the Boards for Stallergenes and Uriach; has received consultancy fees from Meda; is employed by Optimum Patient Care and University of Edinburgh; has received lecture fees from Meda, Chiesi, Teva, AstraZeneca, and Boehringer Ingelheim; has received payment for developing educational presentation from Meda; and is Chairman of the European Academy of Allergy and Clinical Immunology (EAACI) Primary Care Interest Group. A. Valiulis is a board member without financial interest of the nonprofit organizations the European Academy of Paediatrics, European Paediatrc Association, European Confederation of Primary Care Paediatricians, Lithuanian Paediatric Society, and Lithuanian Paediatric Respiratory Society; has received research support from European Union Social Fund and Lithuanian Ministry of Health; has received travel support from the European Academy of Pediatrics; is Chairman of Executive Board of IPOKRaTES Lithuania Fund. E. Valovirta has received travel support from Stallergenes. M. Wickman has received research support and lecture fees from Thermo Fisher, has received consultancy fees from Thermo Fisher and Microtest Dx, and has received payment for developing educational presentations from Stallergenes. T. Zuberbier has received consultancy fees from Ansell, Bayer Schering, DST, FAES, Fujisawa, HAL, Henkel, Kryolan, Leti, Menarini, Merck, MSD, Novartis, Procter & Gamble, Ranbaxy, Sanofi-Aventis, Schering Plough, Stallergenes, Takeda, and UCB; is on the German Society for Allergy and Clinical Immunology Scientific Advisory Board; is head of the European Centre for Allergy Research Foundation; is a World Health Organization Initiative Allergic Rhinitis and its Impact on Asthma committee member; is a member of the World Allergy Organization Communications Council; and is Secretary General of the Global Allergy and Asthma European Network. The rest of the authors declare that they have no relevant conflicts of interest.
Publisher Copyright:
© 2016 The Authors
ID: 311566112