Lymphatic drainage affects lipolytic activity of femoral adipose tissue in women
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Lymphatic drainage affects lipolytic activity of femoral adipose tissue in women. / Varaliova, Zuzana; Vlasak, Rene; Cizkova, Terezie; Gojda, Jan; Potockova, Jana; Siklova, Michaela; Krauzova, Eva; Stepan, Marek; Bulow, Jens; Stich, Vladimir; Rossmeislova, Lenka.
I: International Journal of Obesity, Bind 44, 2020, s. 1974–1978.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Lymphatic drainage affects lipolytic activity of femoral adipose tissue in women
AU - Varaliova, Zuzana
AU - Vlasak, Rene
AU - Cizkova, Terezie
AU - Gojda, Jan
AU - Potockova, Jana
AU - Siklova, Michaela
AU - Krauzova, Eva
AU - Stepan, Marek
AU - Bulow, Jens
AU - Stich, Vladimir
AU - Rossmeislova, Lenka
PY - 2020
Y1 - 2020
N2 - It has been shown that many molecules released by adipose tissue (AT) into interstitial fluid can reach the bloodstream preferentially via lymphatic system. Worsened lymphatic drainage may alter interstitial fluid (ISF) composition and thus affect microenvironment of adipocytes. Nevertheless, the effect of lymphatic drainage on AT functions remains unknown. Therefore, we analyzed the lipolytic activity of femoral AT in two groups of premenopausal women similar in adiposity but differing in the efficiency of lymphatic drainage of lower body as assessed by lymphoscintigraphy. Levels of lipolytic markers were assessed in plasma and ISF collected by skin blister technique in femoral area. In addition, microdialysis was used to monitor lipolysis of AT in vivo. Our results indicate that worsened lymphatic drainage is associated with lower in vivo lipolytic index and reduced lipolytic responsiveness of femoral AT to adrenergic stimuli. Thus, efficiency of lymphatic drainage appears to play a role in the regulation of AT metabolism. Accordingly, worsened lymphatic drainage could contribute to the resistance of lower body AT to intentional weigh loss.
AB - It has been shown that many molecules released by adipose tissue (AT) into interstitial fluid can reach the bloodstream preferentially via lymphatic system. Worsened lymphatic drainage may alter interstitial fluid (ISF) composition and thus affect microenvironment of adipocytes. Nevertheless, the effect of lymphatic drainage on AT functions remains unknown. Therefore, we analyzed the lipolytic activity of femoral AT in two groups of premenopausal women similar in adiposity but differing in the efficiency of lymphatic drainage of lower body as assessed by lymphoscintigraphy. Levels of lipolytic markers were assessed in plasma and ISF collected by skin blister technique in femoral area. In addition, microdialysis was used to monitor lipolysis of AT in vivo. Our results indicate that worsened lymphatic drainage is associated with lower in vivo lipolytic index and reduced lipolytic responsiveness of femoral AT to adrenergic stimuli. Thus, efficiency of lymphatic drainage appears to play a role in the regulation of AT metabolism. Accordingly, worsened lymphatic drainage could contribute to the resistance of lower body AT to intentional weigh loss.
KW - CAPILLARY
KW - FAT
U2 - 10.1038/s41366-020-0559-x
DO - 10.1038/s41366-020-0559-x
M3 - Journal article
C2 - 32139870
VL - 44
SP - 1974
EP - 1978
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
ER -
ID: 248155460