Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists

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Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists. / Ara, Ignacio; Auerbach, Pernille; Larsen, Steen; Mata, Esmeralda; Stallknecht, Bente; Ploug, Thorkil; Prats, Clara; Helge, Jorn W.

I: Biomedicines, Bind 8, Nr. 5, 123, 2020.

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

Harvard

Ara, I, Auerbach, P, Larsen, S, Mata, E, Stallknecht, B, Ploug, T, Prats, C & Helge, JW 2020, 'Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists', Biomedicines, bind 8, nr. 5, 123. https://doi.org/10.3390/biomedicines8050123

APA

Ara, I., Auerbach, P., Larsen, S., Mata, E., Stallknecht, B., Ploug, T., ... Helge, J. W. (2020). Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists. Biomedicines, 8(5), [123]. https://doi.org/10.3390/biomedicines8050123

Vancouver

Ara I, Auerbach P, Larsen S, Mata E, Stallknecht B, Ploug T o.a. Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists. Biomedicines. 2020;8(5). 123. https://doi.org/10.3390/biomedicines8050123

Author

Ara, Ignacio ; Auerbach, Pernille ; Larsen, Steen ; Mata, Esmeralda ; Stallknecht, Bente ; Ploug, Thorkil ; Prats, Clara ; Helge, Jorn W. / Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists. I: Biomedicines. 2020 ; Bind 8, Nr. 5.

Bibtex

@article{a765186711524660b8fbc2a040d1c230,
title = "Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists",
abstract = "Macrophage infiltration in two subcutaneous adipose tissue depots and systemic low-grade inflammation were studied in post-obese (PO), obese (O), and control (C) subjects. Young males were recruited into PO: (n = 10, weight-loss avg. 26{\%}, BMI: 26.6 +/- 0.7, mean +/- SEM kg/m(2)), O: (n = 10, BMI: 33.8 +/- 1.0kg/m(2)) and C: (n = 10, BMI: 26.6 +/- 0.6 kg/m(2)). PO and C were matched by BMI. Blood and abdominal and gluteal subcutaneous adipose tissue were obtained in the overnight fasted state. Plasma concentrations of IL-6 and CRP were higher (p < 0.05) in O than in PO and C, TNF-alpha was higher (p < 0.05) only in O compared to PO and IL-18 was similar between groups. The number of CD68(+) macrophages was higher (p < 0.05) in the gluteal than the abdominal depot, and higher (p < 0.05) in O and PO compared to C in both depots. The content of CD163(+) macrophages was similar between depots but was higher (p < 0.05) in PO compared to C and O in the gluteal depot. In post obese men with a long-term sustained weight loss, systemic low-grade inflammation was similar to non-obese controls despite a higher subcutaneous adipose tissue CD68(+) macrophage content. Interestingly, the anti-inflammatory CD163(+) macrophage adipose tissue content was consistently higher in post obese than obese and controls.",
keywords = "obesity, abdominal, gluteal, cytokines, weight loss",
author = "Ignacio Ara and Pernille Auerbach and Steen Larsen and Esmeralda Mata and Bente Stallknecht and Thorkil Ploug and Clara Prats and Helge, {Jorn W.}",
year = "2020",
doi = "10.3390/biomedicines8050123",
language = "English",
volume = "8",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI AG",
number = "5",

}

RIS

TY - JOUR

T1 - Low-Grade Inflammation Is Not Present in Former Obese Males but Adipose Tissue Macrophage Infiltration Persists

AU - Ara, Ignacio

AU - Auerbach, Pernille

AU - Larsen, Steen

AU - Mata, Esmeralda

AU - Stallknecht, Bente

AU - Ploug, Thorkil

AU - Prats, Clara

AU - Helge, Jorn W.

PY - 2020

Y1 - 2020

N2 - Macrophage infiltration in two subcutaneous adipose tissue depots and systemic low-grade inflammation were studied in post-obese (PO), obese (O), and control (C) subjects. Young males were recruited into PO: (n = 10, weight-loss avg. 26%, BMI: 26.6 +/- 0.7, mean +/- SEM kg/m(2)), O: (n = 10, BMI: 33.8 +/- 1.0kg/m(2)) and C: (n = 10, BMI: 26.6 +/- 0.6 kg/m(2)). PO and C were matched by BMI. Blood and abdominal and gluteal subcutaneous adipose tissue were obtained in the overnight fasted state. Plasma concentrations of IL-6 and CRP were higher (p < 0.05) in O than in PO and C, TNF-alpha was higher (p < 0.05) only in O compared to PO and IL-18 was similar between groups. The number of CD68(+) macrophages was higher (p < 0.05) in the gluteal than the abdominal depot, and higher (p < 0.05) in O and PO compared to C in both depots. The content of CD163(+) macrophages was similar between depots but was higher (p < 0.05) in PO compared to C and O in the gluteal depot. In post obese men with a long-term sustained weight loss, systemic low-grade inflammation was similar to non-obese controls despite a higher subcutaneous adipose tissue CD68(+) macrophage content. Interestingly, the anti-inflammatory CD163(+) macrophage adipose tissue content was consistently higher in post obese than obese and controls.

AB - Macrophage infiltration in two subcutaneous adipose tissue depots and systemic low-grade inflammation were studied in post-obese (PO), obese (O), and control (C) subjects. Young males were recruited into PO: (n = 10, weight-loss avg. 26%, BMI: 26.6 +/- 0.7, mean +/- SEM kg/m(2)), O: (n = 10, BMI: 33.8 +/- 1.0kg/m(2)) and C: (n = 10, BMI: 26.6 +/- 0.6 kg/m(2)). PO and C were matched by BMI. Blood and abdominal and gluteal subcutaneous adipose tissue were obtained in the overnight fasted state. Plasma concentrations of IL-6 and CRP were higher (p < 0.05) in O than in PO and C, TNF-alpha was higher (p < 0.05) only in O compared to PO and IL-18 was similar between groups. The number of CD68(+) macrophages was higher (p < 0.05) in the gluteal than the abdominal depot, and higher (p < 0.05) in O and PO compared to C in both depots. The content of CD163(+) macrophages was similar between depots but was higher (p < 0.05) in PO compared to C and O in the gluteal depot. In post obese men with a long-term sustained weight loss, systemic low-grade inflammation was similar to non-obese controls despite a higher subcutaneous adipose tissue CD68(+) macrophage content. Interestingly, the anti-inflammatory CD163(+) macrophage adipose tissue content was consistently higher in post obese than obese and controls.

KW - obesity

KW - abdominal

KW - gluteal

KW - cytokines

KW - weight loss

U2 - 10.3390/biomedicines8050123

DO - 10.3390/biomedicines8050123

M3 - Journal article

C2 - 32423179

VL - 8

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 5

M1 - 123

ER -

ID: 244327220