Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

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Standard

Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice. / Delle, Christine; Cankar, Neža; Digebjerg Holgersson, Christian; Hvorup Knudsen, Helle; Schiøler Nielsen, Elise; Kjaerby, Celia; Mori, Yuki; Nedergaard, Maiken; Weikop, Pia.

I: Scientific Reports, Bind 13, Nr. 1, 4137, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Delle, C, Cankar, N, Digebjerg Holgersson, C, Hvorup Knudsen, H, Schiøler Nielsen, E, Kjaerby, C, Mori, Y, Nedergaard, M & Weikop, P 2023, 'Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice', Scientific Reports, bind 13, nr. 1, 4137. https://doi.org/10.1038/s41598-023-30630-y

APA

Delle, C., Cankar, N., Digebjerg Holgersson, C., Hvorup Knudsen, H., Schiøler Nielsen, E., Kjaerby, C., Mori, Y., Nedergaard, M., & Weikop, P. (2023). Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice. Scientific Reports, 13(1), [4137]. https://doi.org/10.1038/s41598-023-30630-y

Vancouver

Delle C, Cankar N, Digebjerg Holgersson C, Hvorup Knudsen H, Schiøler Nielsen E, Kjaerby C o.a. Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice. Scientific Reports. 2023;13(1). 4137. https://doi.org/10.1038/s41598-023-30630-y

Author

Delle, Christine ; Cankar, Neža ; Digebjerg Holgersson, Christian ; Hvorup Knudsen, Helle ; Schiøler Nielsen, Elise ; Kjaerby, Celia ; Mori, Yuki ; Nedergaard, Maiken ; Weikop, Pia. / Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice. I: Scientific Reports. 2023 ; Bind 13, Nr. 1.

Bibtex

@article{da9b3d5252d7481695d548ff70b0c7ed,
title = "Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice",
abstract = "Obesity affects millions of people worldwide and is associated with an increased risk of cognitive decline. The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia. We herein examined glymphatic transport in mice with long-term obesity induced by a high-fat diet for 10 months. The obese mice developed hypertension and elevated heart rate, neuroinflammation and gliosis, but not apparent systemic inflammation. Surprisingly, glymphatic inflow was globally unaffected by the high-fat diet except for the hypothalamus, which displayed increased influx and elevated AQP4 vascular polarization compared to the normal weight control group. We propose that a long-term high-fat diet induced metabolic alteration of hypothalamic neurons and neuroinflammation, which in turn enhanced glymphatic clearance in the effected brain region.",
keywords = "Mice, Animals, Diet, High-Fat/adverse effects, Neuroinflammatory Diseases, Brain/physiology, Hypothalamus/metabolism, Obesity/etiology, Mice, Inbred C57BL",
author = "Christine Delle and Ne{\v z}a Cankar and {Digebjerg Holgersson}, Christian and {Hvorup Knudsen}, Helle and {Schi{\o}ler Nielsen}, Elise and Celia Kjaerby and Yuki Mori and Maiken Nedergaard and Pia Weikop",
note = "{\textcopyright} 2023. The Author(s).",
year = "2023",
doi = "10.1038/s41598-023-30630-y",
language = "English",
volume = "13",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice

AU - Delle, Christine

AU - Cankar, Neža

AU - Digebjerg Holgersson, Christian

AU - Hvorup Knudsen, Helle

AU - Schiøler Nielsen, Elise

AU - Kjaerby, Celia

AU - Mori, Yuki

AU - Nedergaard, Maiken

AU - Weikop, Pia

N1 - © 2023. The Author(s).

PY - 2023

Y1 - 2023

N2 - Obesity affects millions of people worldwide and is associated with an increased risk of cognitive decline. The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia. We herein examined glymphatic transport in mice with long-term obesity induced by a high-fat diet for 10 months. The obese mice developed hypertension and elevated heart rate, neuroinflammation and gliosis, but not apparent systemic inflammation. Surprisingly, glymphatic inflow was globally unaffected by the high-fat diet except for the hypothalamus, which displayed increased influx and elevated AQP4 vascular polarization compared to the normal weight control group. We propose that a long-term high-fat diet induced metabolic alteration of hypothalamic neurons and neuroinflammation, which in turn enhanced glymphatic clearance in the effected brain region.

AB - Obesity affects millions of people worldwide and is associated with an increased risk of cognitive decline. The glymphatic system is a brain-wide metabolic waste clearance system, dysfunction of which is linked to dementia. We herein examined glymphatic transport in mice with long-term obesity induced by a high-fat diet for 10 months. The obese mice developed hypertension and elevated heart rate, neuroinflammation and gliosis, but not apparent systemic inflammation. Surprisingly, glymphatic inflow was globally unaffected by the high-fat diet except for the hypothalamus, which displayed increased influx and elevated AQP4 vascular polarization compared to the normal weight control group. We propose that a long-term high-fat diet induced metabolic alteration of hypothalamic neurons and neuroinflammation, which in turn enhanced glymphatic clearance in the effected brain region.

KW - Mice

KW - Animals

KW - Diet, High-Fat/adverse effects

KW - Neuroinflammatory Diseases

KW - Brain/physiology

KW - Hypothalamus/metabolism

KW - Obesity/etiology

KW - Mice, Inbred C57BL

U2 - 10.1038/s41598-023-30630-y

DO - 10.1038/s41598-023-30630-y

M3 - Journal article

C2 - 36914703

VL - 13

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 4137

ER -

ID: 345509581