Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly

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Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly. / Han, Changwoo; Oh, Jongmin; Lim, Youn-Hee; Kim, Soontae; Hong, Yun-Chul.

I: Environment International, Bind 143, 105895, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Han, C, Oh, J, Lim, Y-H, Kim, S & Hong, Y-C 2020, 'Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly', Environment International, bind 143, 105895. https://doi.org/10.1016/j.envint.2020.105895

APA

Han, C., Oh, J., Lim, Y-H., Kim, S., & Hong, Y-C. (2020). Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly. Environment International, 143, [105895]. https://doi.org/10.1016/j.envint.2020.105895

Vancouver

Han C, Oh J, Lim Y-H, Kim S, Hong Y-C. Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly. Environment International. 2020;143. 105895. https://doi.org/10.1016/j.envint.2020.105895

Author

Han, Changwoo ; Oh, Jongmin ; Lim, Youn-Hee ; Kim, Soontae ; Hong, Yun-Chul. / Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly. I: Environment International. 2020 ; Bind 143.

Bibtex

@article{5a5a38346f4940fd8c15f36d0859d410,

title = "Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly",

abstract = "BACKGROUND: Studies evaluating the role of long-term exposure to fine particulate matter (PM2.5) on chronic obstructive pulmonary disease (COPD) development showed inconsistent results and were limited to Western countries. We aimed to determine the association between long-term exposure to PM2.5 and COPD development in metropolitan cities in Korea, which have higher PM2.5 levels than those in Western country studies.METHODS: We constructed a retrospective cohort (elderly aged over 65 years who resided in 7 metropolitan cities in 2008) using Korea health insurance data. A total of 687,940 elderlies who had not visited hospitals due to COPD for 3 years (from 2008 to 2010) were followed-up from 2011 to 2016. The first hospital visit due to COPD during the follow-up period was regarded as COPD development. Daily district-level PM2.5 concentrations were estimated by chemical transport model and 60-month moving average PM2.5 were assigned to each subject in time-varying Cox proportional hazard model.RESULTS: The mean concentration of modelled PM2.5 in 7 metropolitan cities during the study period (from 2006 to 2016) was 28.0 μg/m3 and 259,700 subjects newly visited the hospital due to COPD. COPD hospital visit hazard ratio for a 10 μg/m3 increase in 60-month moving average PM2.5 concentration was 1.09 (95% confidence interval: 1.07, 1.11). Risks remained unchanged following different PM2.5 exposure levels (48-month moving average, and average PM2.5 concentrations for 2008 and 2008-2010) and in subgroup analysis by subject characteristics (sex, age, and income groups).DISCUSSION: By following-up 687,940 elderly subjects who resided in metropolitan cities in Korea for 6 years, long-term PM2.5 exposure showed association with COPD development.",

author = "Changwoo Han and Jongmin Oh and Youn-Hee Lim and Soontae Kim and Yun-Chul Hong",

year = "2020",

doi = "10.1016/j.envint.2020.105895",

language = "English",

volume = "143",

journal = "Environment international",

issn = "0160-4120",

publisher = "Pergamon Press",

}

RIS

TY - JOUR

T1 - Long-term exposure to fine particulate matter and development of chronic obstructive pulmonary disease in the elderly

AU - Han, Changwoo

AU - Oh, Jongmin

AU - Lim, Youn-Hee

AU - Kim, Soontae

AU - Hong, Yun-Chul

PY - 2020

Y1 - 2020

N2 - BACKGROUND: Studies evaluating the role of long-term exposure to fine particulate matter (PM2.5) on chronic obstructive pulmonary disease (COPD) development showed inconsistent results and were limited to Western countries. We aimed to determine the association between long-term exposure to PM2.5 and COPD development in metropolitan cities in Korea, which have higher PM2.5 levels than those in Western country studies.METHODS: We constructed a retrospective cohort (elderly aged over 65 years who resided in 7 metropolitan cities in 2008) using Korea health insurance data. A total of 687,940 elderlies who had not visited hospitals due to COPD for 3 years (from 2008 to 2010) were followed-up from 2011 to 2016. The first hospital visit due to COPD during the follow-up period was regarded as COPD development. Daily district-level PM2.5 concentrations were estimated by chemical transport model and 60-month moving average PM2.5 were assigned to each subject in time-varying Cox proportional hazard model.RESULTS: The mean concentration of modelled PM2.5 in 7 metropolitan cities during the study period (from 2006 to 2016) was 28.0 μg/m3 and 259,700 subjects newly visited the hospital due to COPD. COPD hospital visit hazard ratio for a 10 μg/m3 increase in 60-month moving average PM2.5 concentration was 1.09 (95% confidence interval: 1.07, 1.11). Risks remained unchanged following different PM2.5 exposure levels (48-month moving average, and average PM2.5 concentrations for 2008 and 2008-2010) and in subgroup analysis by subject characteristics (sex, age, and income groups).DISCUSSION: By following-up 687,940 elderly subjects who resided in metropolitan cities in Korea for 6 years, long-term PM2.5 exposure showed association with COPD development.

AB - BACKGROUND: Studies evaluating the role of long-term exposure to fine particulate matter (PM2.5) on chronic obstructive pulmonary disease (COPD) development showed inconsistent results and were limited to Western countries. We aimed to determine the association between long-term exposure to PM2.5 and COPD development in metropolitan cities in Korea, which have higher PM2.5 levels than those in Western country studies.METHODS: We constructed a retrospective cohort (elderly aged over 65 years who resided in 7 metropolitan cities in 2008) using Korea health insurance data. A total of 687,940 elderlies who had not visited hospitals due to COPD for 3 years (from 2008 to 2010) were followed-up from 2011 to 2016. The first hospital visit due to COPD during the follow-up period was regarded as COPD development. Daily district-level PM2.5 concentrations were estimated by chemical transport model and 60-month moving average PM2.5 were assigned to each subject in time-varying Cox proportional hazard model.RESULTS: The mean concentration of modelled PM2.5 in 7 metropolitan cities during the study period (from 2006 to 2016) was 28.0 μg/m3 and 259,700 subjects newly visited the hospital due to COPD. COPD hospital visit hazard ratio for a 10 μg/m3 increase in 60-month moving average PM2.5 concentration was 1.09 (95% confidence interval: 1.07, 1.11). Risks remained unchanged following different PM2.5 exposure levels (48-month moving average, and average PM2.5 concentrations for 2008 and 2008-2010) and in subgroup analysis by subject characteristics (sex, age, and income groups).DISCUSSION: By following-up 687,940 elderly subjects who resided in metropolitan cities in Korea for 6 years, long-term PM2.5 exposure showed association with COPD development.

U2 - 10.1016/j.envint.2020.105895

DO - 10.1016/j.envint.2020.105895

M3 - Journal article

C2 - 32615346

VL - 143

JO - Environment international

JF - Environment international

SN - 0160-4120

M1 - 105895

ER -

ID: 244446612