Long-term exposure to air pollution and incidence of adult-onset asthma and COPD: systematic review and metaanalyses

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningfagfællebedømt

Background: Long-term exposure to air pollution has been linked to chronic respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). However, inconsistencies in results remain. We systematically review the evidence on the association of long-term exposure to air pollution with adult-onset asthma and COPD incidence, separately.

Methods: We systematically searched PubMed and Web of Science from databases inception to January 31st, 2022. Two reviewers independently reviewed articles for eligibility. We included cohort and case-control studies on the association of long-term air pollution exposure with incidence of adult-onset asthma and COPD, including first-ever hospital admission, medication use, spirometry test, and self-reported doctor diagnosis. A random-effect meta-analysis was performed when at least three studies were available for a specific exposure-outcome pair.

Results: 19 and 18 studies for adult-onset asthma and COPD, respectively, met the inclusion criteria for meta-analysis. Studies were mainly conducted in Europe (9 for asthma, 8 for COPD), North America (7 for both) and Western Pacific region (3 for both). We observed positive associations of adult-onset asthma with PM2.5 (hazard ratio; 95% confidence interval 1.04; 0.97-1.11 per 5 µg/m3), NO2 (1.10; 1.04-1.17 per 10 µg/m3), and O3 (1.00; 0.91-1.11 per 10 µg/m3). Similarly, we observed positive associations of COPD with PM2.5 (1.04; 0.96-1.12), NO2 (1.01; 0.96-1.07), BC (1.07; 1.02-1.12 per 0.5 10-5m-1), and NOx (1.03; 1.01-1.06 per 10 µg/m3).

Conclusion: Long-term exposure to air pollution, especially NO2 and NOX, was associated with the risk of adult-onset asthma and COPD.
TidsskriftThe European Respiratory Journal
Udgave nummerSuppl.
Antal sider2
StatusUdgivet - 2022

ID: 337782236