Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs. / Wu, Chengyu; Mu, Huiling.

I: Pharmaceutical Nanotechnology, Bind 8, Nr. 1, 2020, s. 22-32.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Wu, C & Mu, H 2020, 'Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs', Pharmaceutical Nanotechnology, bind 8, nr. 1, s. 22-32. https://doi.org/10.2174/2211738507666191029160944

APA

Wu, C., & Mu, H. (2020). Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs. Pharmaceutical Nanotechnology, 8(1), 22-32. https://doi.org/10.2174/2211738507666191029160944

Vancouver

Wu C, Mu H. Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs. Pharmaceutical Nanotechnology. 2020;8(1):22-32. https://doi.org/10.2174/2211738507666191029160944

Author

Wu, Chengyu ; Mu, Huiling. / Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs. I: Pharmaceutical Nanotechnology. 2020 ; Bind 8, Nr. 1. s. 22-32.

Bibtex

@article{14615d282322423c92206163537aed20,
title = "Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs",
abstract = "Solid lipid particles have a great potential in sustained drug delivery, the lipid excipients are solid at room temperature with a slow degradation rate. Poly (D, L-lactic-co-glycolic acid) (PLGA) has been successfully clinically applied for the sustained delivery of peptide drugs. A recent study showed the advantage of hybrid PLGA-lipid microparticles (MPs) over PLGA MPs for the sustained delivery of peptide drug in vivo. In this paper, we briefly present PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP prepared by the double emulsion method and the spray drying method and discuss the effects of excipients on encapsulation efficiency of protein and peptide drugs in the MPs. The pros and cons of PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP as carriers for sustained delivery of protein and peptide drugs are also discussed.",
keywords = "Drug delivery, Hybrid polymer-lipid microparticles, PLGA microparticles, Protein and peptide drugs, Solid lipid microparticles, Sustained release",
author = "Chengyu Wu and Huiling Mu",
year = "2020",
doi = "10.2174/2211738507666191029160944",
language = "English",
volume = "8",
pages = "22--32",
journal = "Pharmaceutical Nanotechnology",
issn = "2211-7385",
publisher = "Bentham Science Publishers",
number = "1",

}

RIS

TY - JOUR

T1 - Lipid and PLGA microparticles for sustained delivery of protein and peptide drugs

AU - Wu, Chengyu

AU - Mu, Huiling

PY - 2020

Y1 - 2020

N2 - Solid lipid particles have a great potential in sustained drug delivery, the lipid excipients are solid at room temperature with a slow degradation rate. Poly (D, L-lactic-co-glycolic acid) (PLGA) has been successfully clinically applied for the sustained delivery of peptide drugs. A recent study showed the advantage of hybrid PLGA-lipid microparticles (MPs) over PLGA MPs for the sustained delivery of peptide drug in vivo. In this paper, we briefly present PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP prepared by the double emulsion method and the spray drying method and discuss the effects of excipients on encapsulation efficiency of protein and peptide drugs in the MPs. The pros and cons of PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP as carriers for sustained delivery of protein and peptide drugs are also discussed.

AB - Solid lipid particles have a great potential in sustained drug delivery, the lipid excipients are solid at room temperature with a slow degradation rate. Poly (D, L-lactic-co-glycolic acid) (PLGA) has been successfully clinically applied for the sustained delivery of peptide drugs. A recent study showed the advantage of hybrid PLGA-lipid microparticles (MPs) over PLGA MPs for the sustained delivery of peptide drug in vivo. In this paper, we briefly present PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP prepared by the double emulsion method and the spray drying method and discuss the effects of excipients on encapsulation efficiency of protein and peptide drugs in the MPs. The pros and cons of PLGA MPs, solid lipid MPs and PLGA lipid hybrid MP as carriers for sustained delivery of protein and peptide drugs are also discussed.

KW - Drug delivery

KW - Hybrid polymer-lipid microparticles

KW - PLGA microparticles

KW - Protein and peptide drugs

KW - Solid lipid microparticles

KW - Sustained release

U2 - 10.2174/2211738507666191029160944

DO - 10.2174/2211738507666191029160944

M3 - Review

C2 - 31663483

AN - SCOPUS:85088220994

VL - 8

SP - 22

EP - 32

JO - Pharmaceutical Nanotechnology

JF - Pharmaceutical Nanotechnology

SN - 2211-7385

IS - 1

ER -

ID: 245611099