Limiting DNA replication to once and only once

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Standard

Limiting DNA replication to once and only once. / Boye, Erik; Løbner-Olesen, Anders; Skarstad, Kirsten.

I: EMBO Reports, Bind 1, Nr. 6, 12.2000, s. 479-483.

Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt

Harvard

Boye, E, Løbner-Olesen, A & Skarstad, K 2000, 'Limiting DNA replication to once and only once', EMBO Reports, bind 1, nr. 6, s. 479-483. https://doi.org/10.1093/embo-reports/kvd116

APA

Boye, E., Løbner-Olesen, A., & Skarstad, K. (2000). Limiting DNA replication to once and only once. EMBO Reports, 1(6), 479-483. https://doi.org/10.1093/embo-reports/kvd116

Vancouver

Boye E, Løbner-Olesen A, Skarstad K. Limiting DNA replication to once and only once. EMBO Reports. 2000 dec.;1(6):479-483. https://doi.org/10.1093/embo-reports/kvd116

Author

Boye, Erik ; Løbner-Olesen, Anders ; Skarstad, Kirsten. / Limiting DNA replication to once and only once. I: EMBO Reports. 2000 ; Bind 1, Nr. 6. s. 479-483.

Bibtex

@article{8ce9dae7b04d445788bc100f9eda0d2d,
title = "Limiting DNA replication to once and only once",
abstract = "In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly replicated chromosomal elements; (ii) regulation of the activity of the DnaA initiator protein; and (iii) sequestration of the dnaA gene promoter. This review represents the first attempt to consider together older and more recent data on such inactivation mechanisms in order to analyze their contributions to the overall tight replication control observed in vivo. All cells have developed mechanisms for origin inactivation, but those of other bacteria and eukaryotic cells are clearly distinct from those of E. coli. Possible differences and similarities are discussed.",
keywords = "Bacterial Proteins/genetics, Chromosomes/metabolism, DNA Methylation, DNA Replication, DNA-Binding Proteins/genetics, Escherichia coli/genetics, Eukaryotic Cells/metabolism, Models, Genetic, Promoter Regions, Genetic",
author = "Erik Boye and Anders L{\o}bner-Olesen and Kirsten Skarstad",
year = "2000",
month = dec,
doi = "10.1093/embo-reports/kvd116",
language = "English",
volume = "1",
pages = "479--483",
journal = "E M B O Reports",
issn = "1469-221X",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Limiting DNA replication to once and only once

AU - Boye, Erik

AU - Løbner-Olesen, Anders

AU - Skarstad, Kirsten

PY - 2000/12

Y1 - 2000/12

N2 - In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly replicated chromosomal elements; (ii) regulation of the activity of the DnaA initiator protein; and (iii) sequestration of the dnaA gene promoter. This review represents the first attempt to consider together older and more recent data on such inactivation mechanisms in order to analyze their contributions to the overall tight replication control observed in vivo. All cells have developed mechanisms for origin inactivation, but those of other bacteria and eukaryotic cells are clearly distinct from those of E. coli. Possible differences and similarities are discussed.

AB - In Escherichia coli cells, the origin of chromosomal replication is temporarily inactivated after initiation has occurred. Origin sequestration is the first line of defence against over-initiation, providing a time window during which the initiation potential can be reduced by: (i) titration of DnaA proteins to newly replicated chromosomal elements; (ii) regulation of the activity of the DnaA initiator protein; and (iii) sequestration of the dnaA gene promoter. This review represents the first attempt to consider together older and more recent data on such inactivation mechanisms in order to analyze their contributions to the overall tight replication control observed in vivo. All cells have developed mechanisms for origin inactivation, but those of other bacteria and eukaryotic cells are clearly distinct from those of E. coli. Possible differences and similarities are discussed.

KW - Bacterial Proteins/genetics

KW - Chromosomes/metabolism

KW - DNA Methylation

KW - DNA Replication

KW - DNA-Binding Proteins/genetics

KW - Escherichia coli/genetics

KW - Eukaryotic Cells/metabolism

KW - Models, Genetic

KW - Promoter Regions, Genetic

U2 - 10.1093/embo-reports/kvd116

DO - 10.1093/embo-reports/kvd116

M3 - Review

C2 - 11263490

VL - 1

SP - 479

EP - 483

JO - E M B O Reports

JF - E M B O Reports

SN - 1469-221X

IS - 6

ER -

ID: 200972320