Light bodies in human pituitary adenomas.
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Light bodies in human pituitary adenomas. / Holck, S; Wewer, U M; Albrechtsen, R.
I: Virchows Archiv, Bind 411, Nr. 4, 1987, s. 311-4.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Light bodies in human pituitary adenomas.
AU - Holck, S
AU - Wewer, U M
AU - Albrechtsen, R
N1 - Keywords: Adenoma; Adult; Female; Humans; Male; Microscopy, Electron; Organoids; Pituitary Hormones; Pituitary Neoplasms
PY - 1987
Y1 - 1987
N2 - Light bodies are large cytoplasmic granules originally described in the gonadotrophic cells of the rat pituitary gland. In order to determine whether similar bodies occur in the human anterior pituitary gland, 89 pituitary adenomas and periadenomatous tissue from 20 cases were examined by transmission electron microscopy. Double membrane bound bodies with filamentous internal structure identical to rodent light bodies were identified in 10 hormone-producing adenomas: 5 PRL, 1 PRL-GH, 2 GH, and 2 ACTH-producing tumours. No light bodies were found in the remaining 79 tumours nor in the pituitary cells in periadenomatous tissue from 20 cases. These results show that some human pituitary adenomas may contain light bodies identical to those seen in gonadotrophs of rat pituitary.
AB - Light bodies are large cytoplasmic granules originally described in the gonadotrophic cells of the rat pituitary gland. In order to determine whether similar bodies occur in the human anterior pituitary gland, 89 pituitary adenomas and periadenomatous tissue from 20 cases were examined by transmission electron microscopy. Double membrane bound bodies with filamentous internal structure identical to rodent light bodies were identified in 10 hormone-producing adenomas: 5 PRL, 1 PRL-GH, 2 GH, and 2 ACTH-producing tumours. No light bodies were found in the remaining 79 tumours nor in the pituitary cells in periadenomatous tissue from 20 cases. These results show that some human pituitary adenomas may contain light bodies identical to those seen in gonadotrophs of rat pituitary.
M3 - Journal article
C2 - 3114943
VL - 411
SP - 311
EP - 314
JO - Virchows Archiv
JF - Virchows Archiv
SN - 0945-6317
IS - 4
ER -
ID: 5236976