TY - JOUR

T1 - Leg oxygen uptake in the initial phase of intense exercise is slowed by a marked reduction in oxygen delivery

AU - Christensen, Peter Møller

AU - Nyberg, Michael Permin

AU - Mortensen, Stefan Peter

AU - Nielsen, Jens Jung

AU - Secher, Niels H.

AU - Damsgaard, Rasmus

AU - Hellsten, Ylva

AU - Bangsbo, Jens

N1 - CURIS 2013 NEXS 124

PY - 2013

Y1 - 2013

N2 - The present study examined if a marked reduction in oxygen delivery, unlike findings with moderate intensity exercise, would slow leg oxygen uptake (VO2) kinetics during intense exercise (86±3% of incremental test peak power). Seven healthy males (26±1 years, mean±SEM) performed one-legged knee-extensor exercise (60±3 W) for 4 min in a control setting (CON) and with arterial infusion of L-NMMA and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P

AB - The present study examined if a marked reduction in oxygen delivery, unlike findings with moderate intensity exercise, would slow leg oxygen uptake (VO2) kinetics during intense exercise (86±3% of incremental test peak power). Seven healthy males (26±1 years, mean±SEM) performed one-legged knee-extensor exercise (60±3 W) for 4 min in a control setting (CON) and with arterial infusion of L-NMMA and indomethacin in the working leg to reduce blood flow by inhibiting formation of nitric oxide and prostanoids (double blockade; DB). In DB leg blood flow (LBF) and oxygen delivery during the first minute of exercise were 25-50% lower (P

U2 - 10.1152/ajpregu.00048.2013

DO - 10.1152/ajpregu.00048.2013

M3 - Journal article

C2 - 23720134

VL - 305

SP - R313-R321

JO - American Journal of Physiology

JF - American Journal of Physiology

SN - 0363-6119

IS - 3

ER -