Laser speckle imaging of intra organ drug distribution
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Laser speckle imaging of intra organ drug distribution. / Postnov, Dmitry D.; Holstein-Rathlou, Niels-Henrik; Sosnovtseva, Olga.
I: Biomedical Optics Express, Bind 6, Nr. 12, 12.2015, s. 5055-5062.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Laser speckle imaging of intra organ drug distribution
AU - Postnov, Dmitry D.
AU - Holstein-Rathlou, Niels-Henrik
AU - Sosnovtseva, Olga
PY - 2015/12
Y1 - 2015/12
N2 - Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.
AB - Laminar flow in arteries causes streaming and uneven distribution of infused agents within the organ. This may lead to misinterpretation of experimental results and affect treatment outcomes. We monitor dynamical changes of superficial cortical blood flow in the rat kidney following different routes of administration of the vasoconstrictor angiotensin II. Our analysis reveals the appearance of large scale oscillations of the blood flow caused by inhomogeneous intra organ drug distribution.
U2 - 10.1364/BOE.6.005055
DO - 10.1364/BOE.6.005055
M3 - Journal article
C2 - 26713217
VL - 6
SP - 5055
EP - 5062
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 12
ER -
ID: 153044633