TY - JOUR

T1 - Laser speckle analysis of retinal vascular dynamics

AU - Neganova, Anastasiia Y.

AU - Postnov, Dmitry D.

AU - Jacobsen, Jens Christian B.

AU - Sosnovtseva, Olga

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Studies of vascular responses are usually performed on isolated vessels or on single vessels in vivo. This allows for precise measurements of diameter or blood flow. However, dynamical responses of the whole microvascular network are difficult to access experimentally. We suggest to use full-field laser speckle imaging to evaluate vascular responses of the retinal network. Image segmentation and vessel recognition algorithms together with response mapping allow us to analyze diameter changes and blood flow responses in the intact retinal network upon systemic administration of the vasoconstrictor angiotensin II, the vasodilator acetylcholine or on the changing level of anesthesia in in vivo rat preparations.

AB - Studies of vascular responses are usually performed on isolated vessels or on single vessels in vivo. This allows for precise measurements of diameter or blood flow. However, dynamical responses of the whole microvascular network are difficult to access experimentally. We suggest to use full-field laser speckle imaging to evaluate vascular responses of the retinal network. Image segmentation and vessel recognition algorithms together with response mapping allow us to analyze diameter changes and blood flow responses in the intact retinal network upon systemic administration of the vasoconstrictor angiotensin II, the vasodilator acetylcholine or on the changing level of anesthesia in in vivo rat preparations.

U2 - 10.1364/BOE.7.001375

DO - 10.1364/BOE.7.001375

M3 - Journal article

C2 - 27446662

VL - 7

SP - 1375

EP - 1384

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 4

ER -