Ketamine as potential treatment for postpartum depression: A narrative review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Standard
Ketamine as potential treatment for postpartum depression : A narrative review. / Chen-Li, David; Lui, Leanna M.W.; Rosenblat, Joshua D.; Lipsitz, Orly; Teopiz, Kayla M.; Ho, Roger; Vinberg, Maj; Golts, Marina; Jawad, Muhammad Youshay; Lee, Yena; Nasri, Flora; Gill, Hartej; McIntyre, Roger S.
I: Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, Bind 34, Nr. 4, 2022, s. 264-274.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Ketamine as potential treatment for postpartum depression
T2 - A narrative review
AU - Chen-Li, David
AU - Lui, Leanna M.W.
AU - Rosenblat, Joshua D.
AU - Lipsitz, Orly
AU - Teopiz, Kayla M.
AU - Ho, Roger
AU - Vinberg, Maj
AU - Golts, Marina
AU - Jawad, Muhammad Youshay
AU - Lee, Yena
AU - Nasri, Flora
AU - Gill, Hartej
AU - McIntyre, Roger S.
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Postpartum depression (PPD) is a severe, debilitating mood disorder with consequences for both mothers and children, highlighting the need for rapid-acting and effective treatments for PPD. The aim of this narrative review is to synthesize the available literature on the administration of ketamine for PPD and propose ketamine as a viable and advantageous treatment. METHODS: A search was conducted on MEDLINE/PubMed, PsycInfo, and Embase databases from inception to October 10, 2021 for preclinical studies, interventional studies (ie, open-label and randomized controlled trials), as well as systematic reviews and meta-analyses evaluating the use of ketamine in postpartum populations. Completed and ongoing clinical trials were identified on ClinicalTrials.gov. RESULTS: Four clinical trials were identified. Results from this review support additional investigation into ketamine as a potential treatment for PPD. CONCLUSIONS: Ketamine may be a favorable option for treating PPD due to its antidepressive and analgesic effects, short infusion time, and rapid clearance from the maternal bloodstream. However, there is insufficient evidence to support its use in this population, underscoring the importance of additional clinical research investigating ketamine for PPD.
AB - BACKGROUND: Postpartum depression (PPD) is a severe, debilitating mood disorder with consequences for both mothers and children, highlighting the need for rapid-acting and effective treatments for PPD. The aim of this narrative review is to synthesize the available literature on the administration of ketamine for PPD and propose ketamine as a viable and advantageous treatment. METHODS: A search was conducted on MEDLINE/PubMed, PsycInfo, and Embase databases from inception to October 10, 2021 for preclinical studies, interventional studies (ie, open-label and randomized controlled trials), as well as systematic reviews and meta-analyses evaluating the use of ketamine in postpartum populations. Completed and ongoing clinical trials were identified on ClinicalTrials.gov. RESULTS: Four clinical trials were identified. Results from this review support additional investigation into ketamine as a potential treatment for PPD. CONCLUSIONS: Ketamine may be a favorable option for treating PPD due to its antidepressive and analgesic effects, short infusion time, and rapid clearance from the maternal bloodstream. However, there is insufficient evidence to support its use in this population, underscoring the importance of additional clinical research investigating ketamine for PPD.
U2 - 10.12788/acp.0082
DO - 10.12788/acp.0082
M3 - Review
C2 - 36282614
AN - SCOPUS:85140855353
VL - 34
SP - 264
EP - 274
JO - Annals of Clinical Psychiatry
JF - Annals of Clinical Psychiatry
SN - 1040-1237
IS - 4
ER -
ID: 325833137