Isolated pigment epithelium detachment: evidence for relation to central serous chorioretinopathy and effect of photodynamic therapy
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Isolated pigment epithelium detachment : evidence for relation to central serous chorioretinopathy and effect of photodynamic therapy. / Arif, Farah; Pryds, Anders; Larsen, Michael.
I: Acta Ophthalmologica, Bind 96, Nr. 8, 2018, s. 821-827.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Isolated pigment epithelium detachment
T2 - evidence for relation to central serous chorioretinopathy and effect of photodynamic therapy
AU - Arif, Farah
AU - Pryds, Anders
AU - Larsen, Michael
N1 - © 2018 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.
PY - 2018
Y1 - 2018
N2 - PURPOSE: To describe clinical characteristics and response to verteporfin therapy (PDT) in eyes with retinal pigment epithelium detachment (PED) in the absence of primary disease other than characteristics compatible with central serous chorioretinopathy (CSC).METHODS: Retrospective review of 634 consecutive patients diagnosed with isolated PED or CSC in one or both eyes in the period from 2007 to 2014 at a single institution.RESULTS: Pigment epithelium detachment (PED) in the absence of primary pathology other than angiographic choroidal hyperpermeability in the incident or fellow eye or manifest CSC in the fellow eye was found in 22 eyes in 19 patients. Follow-up ranged from 4 to 61 months. Five of 19 patients (26%) had classic CSC in the fellow eye. Transition from isolated PED to manifest CSC in the eye with PED was observed in seven eyes (33%) over a median untreated period of observation of 11 months (range, 1-32 months). A single session of PDT followed up 1-6 months later showed full resolution of the PED in seven (78%) of nine eyes. Of the 13 untreated eyes, five eyes (38%) underwent spontaneous resolution of the PED.CONCLUSION: Fellow-eye findings, conversion to CSC, resolution of PED after PDT or, less commonly, spontaneously support that isolated PED is a manifestation of CSC that represents an intermediate stage between pachychoroid and classic CSC. The chance of experiencing resolution of the PED was roughly twice as high with PDT as with untreated observation.
AB - PURPOSE: To describe clinical characteristics and response to verteporfin therapy (PDT) in eyes with retinal pigment epithelium detachment (PED) in the absence of primary disease other than characteristics compatible with central serous chorioretinopathy (CSC).METHODS: Retrospective review of 634 consecutive patients diagnosed with isolated PED or CSC in one or both eyes in the period from 2007 to 2014 at a single institution.RESULTS: Pigment epithelium detachment (PED) in the absence of primary pathology other than angiographic choroidal hyperpermeability in the incident or fellow eye or manifest CSC in the fellow eye was found in 22 eyes in 19 patients. Follow-up ranged from 4 to 61 months. Five of 19 patients (26%) had classic CSC in the fellow eye. Transition from isolated PED to manifest CSC in the eye with PED was observed in seven eyes (33%) over a median untreated period of observation of 11 months (range, 1-32 months). A single session of PDT followed up 1-6 months later showed full resolution of the PED in seven (78%) of nine eyes. Of the 13 untreated eyes, five eyes (38%) underwent spontaneous resolution of the PED.CONCLUSION: Fellow-eye findings, conversion to CSC, resolution of PED after PDT or, less commonly, spontaneously support that isolated PED is a manifestation of CSC that represents an intermediate stage between pachychoroid and classic CSC. The chance of experiencing resolution of the PED was roughly twice as high with PDT as with untreated observation.
KW - Adult
KW - Aged
KW - Central Serous Chorioretinopathy/complications
KW - Female
KW - Fluorescein Angiography
KW - Follow-Up Studies
KW - Fundus Oculi
KW - Humans
KW - Male
KW - Middle Aged
KW - Photochemotherapy/methods
KW - Photosensitizing Agents/therapeutic use
KW - Retinal Detachment/diagnosis
KW - Retinal Pigment Epithelium/drug effects
KW - Retrospective Studies
KW - Tomography, Optical Coherence
KW - Treatment Outcome
KW - Verteporfin/therapeutic use
KW - Visual Acuity
U2 - 10.1111/aos.13838
DO - 10.1111/aos.13838
M3 - Journal article
C2 - 30246489
VL - 96
SP - 821
EP - 827
JO - Acta Ophthalmologica
JF - Acta Ophthalmologica
SN - 1755-375X
IS - 8
ER -
ID: 218355967