Is chronic obstructive pulmonary disease a risk factor for death in patients with community acquired pneumonia?
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Is chronic obstructive pulmonary disease a risk factor for death in patients with community acquired pneumonia? / Bonnesen, Barbara; Baunbæk Egelund, Gertrud; Vestergaard Jensen, Andreas; Andersen, Stine; Trier Petersen, Pelle; Rohde, Gernot; Ravn, Pernille.
I: Infectious diseases (London, England), Bind 51, Nr. 5, 05.2019, s. 340-347.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Is chronic obstructive pulmonary disease a risk factor for death in patients with community acquired pneumonia?
AU - Bonnesen, Barbara
AU - Baunbæk Egelund, Gertrud
AU - Vestergaard Jensen, Andreas
AU - Andersen, Stine
AU - Trier Petersen, Pelle
AU - Rohde, Gernot
AU - Ravn, Pernille
PY - 2019/5
Y1 - 2019/5
N2 - BACKGROUND: It is still a matter of debate whether the outcome of community acquired pneumonia is more severe in patients with chronic obstructive pulmonary disease. We aimed to determine whether chronic obstructive pulmonary disease was associated with increased mortality and to identify risk-factors for mortality in patients with community acquired pneumonia and chronic obstructive pulmonary disease.METHODS: Retrospective cohort study comparing patients with community acquired pneumonia and chronic obstructive pulmonary disease to patients without chronic obstructive pulmonary disease. We included 1309 patients with community acquired pneumonia admitted from 2011 until 2012 (243 patients with chronic obstructive pulmonary disease and 1066 without chronic obstructive pulmonary disease).RESULTS: At admission patients with community acquired pneumonia and chronic obstructive pulmonary disease presented with more severe pneumonia as measured by CURB-65 score compared to patients without chronic obstructive pulmonary disease. Mortality on day 30 was generally high, and higher among patients with community acquired pneumonia and chronic obstructive pulmonary disease compared to those without chronic obstructive pulmonary disease (16.0% versus 11.3%, p = .04). In an adjusted analysis, however, chronic obstructive pulmonary disease was not independently associated with 30-d mortality (odds ratio 0.94, confidence interval 95% 0.59-1.50). Factors related to mortality in patients with community acquired pneumonia and chronic obstructive pulmonary disease were age, premorbid condition, severity of pneumonia as determined by CURB-65 score, and pleural effusion and multi-lobular infiltrate on chest X-ray.CONCLUSIONS: Chronic obstructive pulmonary disease was not independently associated with 30-d mortality in patients with community acquired pneumonia.
AB - BACKGROUND: It is still a matter of debate whether the outcome of community acquired pneumonia is more severe in patients with chronic obstructive pulmonary disease. We aimed to determine whether chronic obstructive pulmonary disease was associated with increased mortality and to identify risk-factors for mortality in patients with community acquired pneumonia and chronic obstructive pulmonary disease.METHODS: Retrospective cohort study comparing patients with community acquired pneumonia and chronic obstructive pulmonary disease to patients without chronic obstructive pulmonary disease. We included 1309 patients with community acquired pneumonia admitted from 2011 until 2012 (243 patients with chronic obstructive pulmonary disease and 1066 without chronic obstructive pulmonary disease).RESULTS: At admission patients with community acquired pneumonia and chronic obstructive pulmonary disease presented with more severe pneumonia as measured by CURB-65 score compared to patients without chronic obstructive pulmonary disease. Mortality on day 30 was generally high, and higher among patients with community acquired pneumonia and chronic obstructive pulmonary disease compared to those without chronic obstructive pulmonary disease (16.0% versus 11.3%, p = .04). In an adjusted analysis, however, chronic obstructive pulmonary disease was not independently associated with 30-d mortality (odds ratio 0.94, confidence interval 95% 0.59-1.50). Factors related to mortality in patients with community acquired pneumonia and chronic obstructive pulmonary disease were age, premorbid condition, severity of pneumonia as determined by CURB-65 score, and pleural effusion and multi-lobular infiltrate on chest X-ray.CONCLUSIONS: Chronic obstructive pulmonary disease was not independently associated with 30-d mortality in patients with community acquired pneumonia.
KW - Aged
KW - Aged, 80 and over
KW - Community-Acquired Infections/complications
KW - Female
KW - Hospital Mortality
KW - Humans
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Patient Admission
KW - Pneumonia/complications
KW - Pulmonary Disease, Chronic Obstructive/complications
KW - Radiography
KW - Retrospective Studies
KW - Risk Factors
KW - Severity of Illness Index
U2 - 10.1080/23744235.2019.1565416
DO - 10.1080/23744235.2019.1565416
M3 - Journal article
C2 - 30938220
VL - 51
SP - 340
EP - 347
JO - Infectious Diseases
JF - Infectious Diseases
SN - 2374-4235
IS - 5
ER -
ID: 234704520