Iron deficiency: Prevalence and relation to cardiovascular biomarkers in heart failure outpatients
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Iron deficiency : Prevalence and relation to cardiovascular biomarkers in heart failure outpatients. / Schou, Morten; Bosselmann, Helle; Gaborit, Freja; Iversen, Kasper; Gøtze, Jens Peter; Soletomas, Georg; Rasmussen, Jon; Kistorp, Caroline; Kober, Lars; Gustafsson, Finn; Tonder, Niels.
I: International Journal of Cardiology, Bind 195, 15.09.2015, s. 143-8.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Iron deficiency
T2 - Prevalence and relation to cardiovascular biomarkers in heart failure outpatients
AU - Schou, Morten
AU - Bosselmann, Helle
AU - Gaborit, Freja
AU - Iversen, Kasper
AU - Gøtze, Jens Peter
AU - Soletomas, Georg
AU - Rasmussen, Jon
AU - Kistorp, Caroline
AU - Kober, Lars
AU - Gustafsson, Finn
AU - Tonder, Niels
N1 - Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
PY - 2015/9/15
Y1 - 2015/9/15
N2 - BACKGROUND: Both iron deficiency (ID) and cardiovascular biomarkers are associated with a poor outcome in heart failure (HF). The relationship between different cardiovascular biomarkers and ID is unknown, and the true prevalence of ID in an outpatient HF clinic is probably overlooked.OBJECTIVES: To identify the prevalence of ID in a HF clinic and evaluate whether ID is associated with increased plasma concentrations of different cardiovascular biomarkers that carry a poor prognosis.METHODS: We prospectively included 149 patients with systolic HF referred to an outpatients HF clinic. ID was defined as ferritin<100 μg/L or ferritin 100-300 μg/L and Tranferin-saturation<0.20. Five different cardiovascular biomarkers were analyzed on frozen plasma.RESULTS: The patients had a median age of 70 (Interquartile range: 64-75) years, 25% were females, 29% were in functional class III-IV and LVEF was 32 (27-39) %. The prevalence of ID was 45% (95%-confidence interval (CI): 37-53%). In multivariate analyses, ID was not associated with plasma concentrations of troponin I, NT-proBNP, MR-proANP, chromogranin A or copeptin (P>0.05 for all) but with plasma concentrations of hs-CRP (odds ratio: 2.03, 95%-CI: 1.02-4.02, P=0.043).CONCLUSION: ID is frequent in an outpatient HF clinic. ID is not associated with cardiovascular biomarkers after adjustment for traditional confounders. Inflammation, but not neurohormonal activation is associated with ID in systolic HF. Further studies are needed to understand iron metabolism in elderly HF patients.
AB - BACKGROUND: Both iron deficiency (ID) and cardiovascular biomarkers are associated with a poor outcome in heart failure (HF). The relationship between different cardiovascular biomarkers and ID is unknown, and the true prevalence of ID in an outpatient HF clinic is probably overlooked.OBJECTIVES: To identify the prevalence of ID in a HF clinic and evaluate whether ID is associated with increased plasma concentrations of different cardiovascular biomarkers that carry a poor prognosis.METHODS: We prospectively included 149 patients with systolic HF referred to an outpatients HF clinic. ID was defined as ferritin<100 μg/L or ferritin 100-300 μg/L and Tranferin-saturation<0.20. Five different cardiovascular biomarkers were analyzed on frozen plasma.RESULTS: The patients had a median age of 70 (Interquartile range: 64-75) years, 25% were females, 29% were in functional class III-IV and LVEF was 32 (27-39) %. The prevalence of ID was 45% (95%-confidence interval (CI): 37-53%). In multivariate analyses, ID was not associated with plasma concentrations of troponin I, NT-proBNP, MR-proANP, chromogranin A or copeptin (P>0.05 for all) but with plasma concentrations of hs-CRP (odds ratio: 2.03, 95%-CI: 1.02-4.02, P=0.043).CONCLUSION: ID is frequent in an outpatient HF clinic. ID is not associated with cardiovascular biomarkers after adjustment for traditional confounders. Inflammation, but not neurohormonal activation is associated with ID in systolic HF. Further studies are needed to understand iron metabolism in elderly HF patients.
KW - Aged
KW - Biomarkers
KW - C-Reactive Protein
KW - Chromogranin A
KW - Comorbidity
KW - Denmark
KW - Female
KW - Ferritins
KW - Glycopeptides
KW - Heart Failure, Systolic
KW - Humans
KW - Iron
KW - Iron Metabolism Disorders
KW - Kaplan-Meier Estimate
KW - Male
KW - Natriuretic Peptide, Brain
KW - Outpatients
KW - Peptide Fragments
KW - Prevalence
KW - Prognosis
KW - Statistics as Topic
KW - Transferrin
KW - Troponin I
U2 - 10.1016/j.ijcard.2015.05.096
DO - 10.1016/j.ijcard.2015.05.096
M3 - Journal article
C2 - 26043148
VL - 195
SP - 143
EP - 148
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -
ID: 160504240