Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
In chronic liver injury, quiescent hepatic stellate cells change into proliferative myofibroblast-like cells, which are a main source of fibrosis. We have recently reported that these cells synthesize ADAM12, a disintegrin and metalloprotease whose expression is up-regulated by TGF-beta1 in liver cancers. Here, we studied the role of the serine/threonine p70S6 kinase (p70S6K) in regulating TGF-beta1-induced ADAM12 expression.
Originalsprog | Engelsk |
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Tidsskrift | Journal of Hepatology |
Vol/bind | 43 |
Udgave nummer | 6 |
Sider (fra-til) | 1038-44 |
Antal sider | 7 |
ISSN | 0168-8278 |
DOI | |
Status | Udgivet - 1 dec. 2005 |
ID: 34325183