Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma. / Rasmussen, Jacob H.; Lelkaitis, Giedrius; Håkansson, Katrin; Vogelius, Ivan R.; Johannesen, Helle H.; Fischer, Barbara M.; Bentzen, Søren M.; Specht, Lena; Kristensen, Claus A.; von Buchwald, Christian; Wessel, Irene; Friborg, Jeppe.
I: British Journal of Cancer, Bind 120, 14.05.2019, s. 1003-1006.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma
AU - Rasmussen, Jacob H.
AU - Lelkaitis, Giedrius
AU - Håkansson, Katrin
AU - Vogelius, Ivan R.
AU - Johannesen, Helle H.
AU - Fischer, Barbara M.
AU - Bentzen, Søren M.
AU - Specht, Lena
AU - Kristensen, Claus A.
AU - von Buchwald, Christian
AU - Wessel, Irene
AU - Friborg, Jeppe
PY - 2019/5/14
Y1 - 2019/5/14
N2 - Intratumor heterogeneity may contribute to the ambiguous clinical results on PD-L1 status as a predictor for immunotherapy response in patients with HNSCC. This decreases the utility of PD-L1 expression from single tumour biopsies as a predictive biomarker. In this prospective study, intratumor heterogeneity of PD-L1 expression in HNSCC was investigated with both Tumour Proportion Score (TPS) and Combined Positive Score (CPS). Thirty-three whole surgical specimens from 28 patients with HNSCC were included. PD-L1 expression in six random core biopsies from each surgical specimen was used to assess the concordance between multiple biopsies and the negative predictive value of a single negative core biopsy. With 1% cut off, 36% of the specimens were concordant with TPS and 52% with CPS. With a 50% cut-off value the concordance was 70% with TPS and 55% with CPS. Defining a tumour as positive if just a single-one of the biopsies was positive, the negative predictive value (NPV) of a single negative core biopsy was 38.9 and 0% (1% cut off), and 79.9% and 62.8% (50% cut off) for TPS and CPS, respectively. In conclusion, PD-L1 positivity varies markedly within the tumour, both with TPS and CPS, challenging the utility of this biomarker.
AB - Intratumor heterogeneity may contribute to the ambiguous clinical results on PD-L1 status as a predictor for immunotherapy response in patients with HNSCC. This decreases the utility of PD-L1 expression from single tumour biopsies as a predictive biomarker. In this prospective study, intratumor heterogeneity of PD-L1 expression in HNSCC was investigated with both Tumour Proportion Score (TPS) and Combined Positive Score (CPS). Thirty-three whole surgical specimens from 28 patients with HNSCC were included. PD-L1 expression in six random core biopsies from each surgical specimen was used to assess the concordance between multiple biopsies and the negative predictive value of a single negative core biopsy. With 1% cut off, 36% of the specimens were concordant with TPS and 52% with CPS. With a 50% cut-off value the concordance was 70% with TPS and 55% with CPS. Defining a tumour as positive if just a single-one of the biopsies was positive, the negative predictive value (NPV) of a single negative core biopsy was 38.9 and 0% (1% cut off), and 79.9% and 62.8% (50% cut off) for TPS and CPS, respectively. In conclusion, PD-L1 positivity varies markedly within the tumour, both with TPS and CPS, challenging the utility of this biomarker.
U2 - 10.1038/s41416-019-0449-y
DO - 10.1038/s41416-019-0449-y
M3 - Journal article
C2 - 30967647
AN - SCOPUS:85064092751
VL - 120
SP - 1003
EP - 1006
JO - The British journal of cancer. Supplement
JF - The British journal of cancer. Supplement
SN - 0007-0920
ER -
ID: 239813908