Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

  • Environmental Determinants of Diabetes in the Young (TEDDY) Group
OBJECTIVE
To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D).

RESEARCH DESIGN AND METHODS
In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron.

RESULTS
We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake.

CONCLUSIONS
Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.
OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind46
Udgave nummer5
Sider (fra-til)1-5
ISSN1935-5548
DOI
StatusUdgivet - 2023

ID: 338435236