Insulin-dependent diabetes: A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia
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Insulin-dependent diabetes : A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia. / Wolthers, Benjamin Ole; Mogensen, Pernille R.; Frandsen, Thomas L.; Abrahamsson, Jonas; Behrendtz, Mikael; Heyman, Mats; Lohi, Olli; Norén-Nyström, Ulrika; Ruud, Ellen; Schmiegelow, Kjeld.
I: Pediatric Blood & Cancer, Bind 66, Nr. 1, e27437, 2019.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Insulin-dependent diabetes
T2 - A chronic complication to acute pancreatitis in childhood acute lymphoblastic leukemia
AU - Wolthers, Benjamin Ole
AU - Mogensen, Pernille R.
AU - Frandsen, Thomas L.
AU - Abrahamsson, Jonas
AU - Behrendtz, Mikael
AU - Heyman, Mats
AU - Lohi, Olli
AU - Norén-Nyström, Ulrika
AU - Ruud, Ellen
AU - Schmiegelow, Kjeld
PY - 2019
Y1 - 2019
N2 - Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.
AB - Pancreatitis is a frequent toxicity to acute lymphoblastic leukemia (ALL) treatment, significantly associated with asparaginase use, and may be followed by severe complications such as acute hyperglycaemia, need for mechanical ventilation, pseudocysts, and death. Here, we provide novel data on seven patients diagnosed with diabetes after pancreatitis and still requiring insulin treatment after a median follow-up of 4.2 years (range: 1.7–9.2). We describe the clinical course of pancreatitis and illustrate the association between pancreatic pseudocysts, older age, and development of insulin-dependent diabetes. Together, this study documents the persisting burden of pancreatitis in childhood ALL and underlines the need for plasma glucose level monitoring.
KW - acute lymphoblastic leukemia
KW - diabetes
KW - pancreatitis
KW - toxicity
U2 - 10.1002/pbc.27437
DO - 10.1002/pbc.27437
M3 - Journal article
C2 - 30216644
AN - SCOPUS:85053481525
VL - 66
JO - Pediatric Blood & Cancer
JF - Pediatric Blood & Cancer
SN - 1545-5009
IS - 1
M1 - e27437
ER -
ID: 223451544